Propofol: An immunomodulating agent
Propofol: An immunomodulating agent
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DOI：
10.1592/phco.2005.25.5_part_2.28s
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发表时间：
2005-05-01
期刊：
影响因子：
4.1
通讯作者：
Marik, PE
中科院分区：
文献类型：
--
作者：
Marik, PE
异丙酚（2,6-二异丙酚）是一种有效的静脉催眠剂，广泛用于诱导和维持麻醉，并在重症监护病房镇静。异丙酚不溶于水，因此配制成脂质乳剂。此外，还添加了一种防腐剂（乙二胺四乙酸[EDTA]或焦亚硫酸钠）来抑制细菌生长。异丙酚具有抗炎特性，减少促炎细胞因子的产生，改变一氧化氮的表达，抑制中性粒细胞功能。异丙酚也是一种有效的抗氧化剂。所添加的防腐剂具有生物活性；EDTA具有抗炎特性，而代谢亚硫酸盐可能引起脂质过氧化。异丙酚的抗炎和抗氧化特性可能对脓毒症和全身炎症反应综合征患者有有益的作用。
Propofol (2,6-diisopropylphenol) is a potent intravenous hypnotic agent widely administered for induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol is insoluble in water and therefore is formulated in a lipid emulsion. In addition, a preservative (ethylenediaminetetraacetic acid [EDTA] or sodium metabisulfite) is added to retard bacterial growth. Propofol has antiinflammatory properties, decreasing production of proinflammatory cytokines, altering expression of nitric oxide, and inhibiting neutrophil function. Propofol also is a potent antioxidant. The added preservatives have biologic activity; EDTA has antiinflammatory properties, whereas metabisulfite may cause lipid peroxidation. The antiinflammatory and antioxidant properties of propofol may have beneficial effects in patients with sepsis and systemic inflammatory response syndrome.