Insular Amyloidosis and Diabetes Mellitus in Macaca Nigra
Insular Amyloidosis and Diabetes Mellitus in Macaca Nigra
复制标题
黑猴的岛状淀粉样变性和糖尿病
DOI：
10.2337/diab.27.4.357
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发表时间：
1978
期刊：
影响因子：
7.7
通讯作者：
C. Howard
中科院分区：
文献类型：
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作者：
C. Howard
黑猕猴胰岛中的淀粉样蛋白随着糖尿病严重程度的增加而增加。胰岛淀粉样蛋白的量被定量，糖尿病猴子的胰岛淀粉样蛋白平均是正常猴子的8倍。岛叶淀粉样蛋白的数量与静脉葡萄糖耐量试验中的葡萄糖清除率显著相关，与空腹过夜后测得的血清葡萄糖、甘油三酯、免疫反应性胰岛素和前β脂蛋白显著相关。与人类一样，岛叶淀粉样蛋白似乎在衰老的猴子中更为普遍。这些结果支持了这样的假设，即相关的胰岛病理和代谢事件，导致胰岛淀粉样蛋白伴随胰岛细胞坏死的出现，可能比迄今为止认识到的更有助于老年人的成熟型糖尿病。
Amyloid in the islets of Langerhans increases with increasing severity of diabetes mellitus in Macaca nigra. The amount of insular amyloid was quantified, and diabetic monkeys averaged eight times more islet amyloid than did normal monkeys. The quantity of insular amyloid correlated significantly with glucose clearance in intravenous glucose tolerance tests and with serum glucose, triglycerides, immunoreactive insulin, and prebetalipoprotein measured after an overnight fast. As with human beings, insular amyloid appeared to be more prevalent in aging monkeys. The results support the hypothesis that the interrelated islet pathologic and metabolic events, which result in the appearance of insular amyloid concomitant with islet cell necrosis, may contribute more to maturity-onset diabetes in aging individuals than has been heretofore realized.