Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons
Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons
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DOI：
10.1038/s41467-020-17270-w
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发表时间：
2020-07-13
影响因子：
16.6
通讯作者：
Hen, Rene
中科院分区：
文献类型：
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作者：
Jimenez, Jessica C.;Berry, Jack E.;Hen, Rene
海马CA1区（vCA1）向杏仁核的投射是情境恐惧记忆所必需的。在这里，我们在小鼠体内使用钙离子成像来评估vCA 1神经元的集合介导的上下文恐惧记忆的编码和检索的时间动态。我们发现，一个子集的vCA 1神经元的厌恶性休克条件反射过程中，他们的活动是必要的记忆编码，这些休克反应神经元富集在vCA 1的杏仁核的投射。在记忆提取过程中，vCA1神经元的群体与休克编码神经元相关，并且该群体内同步活动的幅度与记忆强度成正比。在记忆编码过程中，这些相关网络的出现被抑制vCA 1休克反应所破坏。因此，我们的研究结果表明，与vCA 1中的休克反应神经元相关的细胞网络是情境恐惧记忆集合的重要组成部分。
Ventral hippocampal CA1 (vCA1) projections to the amygdala are necessary for contextual fear memory. Here we used in vivo Ca2+ imaging in mice to assess the temporal dynamics by which ensembles of vCA1 neurons mediate encoding and retrieval of contextual fear memories. We found that a subset of vCA1 neurons were responsive to the aversive shock during context conditioning, their activity was necessary for memory encoding, and these shock-responsive neurons were enriched in the vCA1 projection to the amygdala. During memory retrieval, a population of vCA1 neurons became correlated with shock-encoding neurons, and the magnitude of synchronized activity within this population was proportional to memory strength. The emergence of these correlated networks was disrupted by inhibiting vCA1 shock responses during memory encoding. Thus, our findings suggest that networks of cells that become correlated with shock-responsive neurons in vCA1 are essential components of contextual fear memory ensembles.