Amygdala dysfunction attenuates frustration-induced aggression in psychopathic individuals in a non-criminal population.
Amygdala dysfunction attenuates frustration-induced aggression in psychopathic individuals in a non-criminal population.
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DOI：
10.1016/j.jad.2012.05.012
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发表时间：
2012-12
影响因子：
6.6
通讯作者：
T. Osumi;Takashi Nakao;Yukinori Kasuya;J. Shinoda;J. Yamada;H. Ohira
中科院分区：
文献类型：
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作者：
T. Osumi;Takashi Nakao;Yukinori Kasuya;J. Shinoda;J. Yamada;H. Ohira
背景精神变态者更容易出现某些类型的攻击行为。我们假设，与被监禁的不成功的精神病患者相比，没有犯罪前科但可以根据人格特征被诊断为精神病的成功的精神病患者善于调节攻击性冲动。方法在这项分块设计的功能磁共振成像（fMRI）研究中，我们试图阐明非犯罪人群中挫折诱发的攻击行为与精神病的函数之间存在差异的神经机制。二十名完成自我报告精神病问卷的男本科生在完成一项任务时接受了扫描，在该任务中他们可以或不能惩罚提出不公平金钱分配提议的其他人。结果具有高度精神病倾向的个人不太可能做出对提出不公平提议的人施加昂贵惩罚的决定。在这个决策过程中，精神变态与杏仁核活动减少有关，以应对不公平的报价。此外，与没有惩罚时相比，当有惩罚时，精神病个体的杏仁核功能障碍与多巴胺能相关区域（包括纹状体）的功能连接减少有关。局限性不能排除正常人群中精神病特征水平比监禁人群更轻的可能性。结论研究结果表明，杏仁核功能障碍是精神病患者情感缺陷的基础。我们认为，杏仁核对社会刺激的情感意义不敏感，导致违反社会规范的风险增加，但增强了成功的精神病患者减弱适应不良攻击冲动的能力。
BACKGROUNDIndividuals with psychopathy have an increased tendency toward certain types of aggression. We hypothesized that successful psychopaths, who have no criminal convictions but can be diagnosed with psychopathy in terms of personality characteristics, are skilled at regulating aggressive impulses, compared to incarcerated unsuccessful psychopaths.MethodsIn this block-designed functional magnetic resonance imaging (fMRI) study, we sought to clarify the neural mechanisms underlying differences in frustration-induced aggression as a function of psychopathy in non-criminal populations. Twenty male undergraduate students who completed a self-report psychopathy questionnaire were scanned while they completed a task in which they either could or could not punish other individuals who made unfair offers of monetary distribution.RESULTSIndividuals with high psychopathic tendencies were less likely to make a decision to inflict costly punishment on people proposing unfair offers. During this decision-making, psychopathy was associated with less amygdala activity in response to the unfairness of offers. Moreover, the amygdala dysfunction in psychopathic individuals was associated with reduced functional connectivity with dopaminergic-related areas, including the striatum, when punishment was available compared to when it was unavailable.LimitationsThe possibility that levels of psychopathic traits in a regular population were milder than in incarcerated populations cannot be ruled out.CONCLUSIONSThe findings indicate that amygdala dysfunction underlies affective deficits of psychopathy. We propose that the insensitivity of the amygdala to the affective significance of social stimuli contributes to an increased risk of violation of social norms, but enhances the ability to attenuate impulses toward maladaptive aggression in successful psychopaths.