IFN-γ-dependent inhibition of tumor angiogenesis by tumor-infiltrating CD4+ T cells requires tumor responsiveness to IFN-γ
IFN-γ-dependent inhibition of tumor angiogenesis by tumor-infiltrating CD4+ T cells requires tumor responsiveness to IFN-γ
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DOI：
10.4049/jimmunol.166.4.2276
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发表时间：
2001-02-15
影响因子：
4.4
通讯作者：
Paterson, Y
中科院分区：
文献类型：
--
作者：
Beatty, GL;Paterson, Y
CD 4（+）T细胞在诱导最佳抗肿瘤免疫应答中的重要性很大程度上归因于它们为MHC I类限制性CD 8（+）CTL的引发提供共刺激信号的能力。然而，许多报道已经证明在肿瘤排斥的效应期需要CD 4（+）T细胞，这表明CD 4（+）T细胞在控制肿瘤生长中具有更大的责任。我们在这里证明了CD 4（+）T细胞通过抑制肿瘤血管生成在抑制初始肿瘤发展中的关键作用。使用对IFN-γ无反应的肿瘤变体，我们表明肿瘤对IFN-γ的反应性是CD 4（+）T细胞对肿瘤血管生成的IFN-γ依赖性抑制所必需的。这些研究揭示了CD 4（+）T细胞通过抑制肿瘤血管生成在控制早期肿瘤发展中的关键作用。
The importance of CD4(+) T cells in the induction of an optimal antitumor immune response has largely been attributed to their ability to provide costimulatory signals for the priming of MHC class I-restricted CD8(+) CTL However, many reports have demonstrated a requirement for CD4(+) T cells in the effector phase of tumor rejection indicating a greater responsibility for CD4(+) T cells in controlling tumor outgrowth. We demonstrate here a critical role for CD4(+) T cells in restraining initial tumor development through the inhibition of tumor angiogenesis, Using a tumor variant that is unresponsive to IFN-gamma, we show that tumor responsiveness to IFN-gamma is necessary for IFN-gamma -dependent inhibition of tumor angiogenesis by CD4(+) T cells. These studies reveal a pivotal role for CD4(+) T cells in controlling early tumor development through inhibition of tumor angiogenesis.