Analysis of spinal cord proteome in the rats with mechanical allodynia after the spinal nerve injury
Analysis of spinal cord proteome in the rats with mechanical allodynia after the spinal nerve injury
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DOI：
10.1023/b:bile.0000007068.97472.89
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发表时间：
2003-12-01
影响因子：
2.7
通讯作者：
Kim, HJ
中科院分区：
文献类型：
--
作者：
Lee, SC;Yoon, TG;Kim, HJ
通过蛋白质组学分析，鉴定与周围神经损伤后神经性疼痛相关的蛋白质。五种蛋白在三组大鼠中表现出不同的表达水平。在这些蛋白中，疼痛阳性大鼠的肌酸激酶B表达水平低于假手术或疼痛阴性大鼠。因此，较低的肌酸激酶B表达水平在神经性疼痛的发生和维持中可能是重要的。
Proteome analysis was carried out to identify the proteins associated with neuropathic pain after peripheral nerve injury. Five proteins displayed different expression levels among three groups of rats. Among these proteins, creatine kinase B expression level was lower in the pain-positive rats compared to the sham or pain-negative rats. Therefore, a lower creatine kinase B expression level may be important in the development and maintenance of neuropathic pain.