Augmentation index and carotid intima-media thickness are differently related to age, C-reactive protein and oxidized low-density lipoprotein
Augmentation index and carotid intima-media thickness are differently related to age, C-reactive protein and oxidized low-density lipoprotein
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DOI：
10.1097/hjh.0b013e328014952b
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发表时间：
2007-04-01
影响因子：
4.9
通讯作者：
Zilmer, Mihkel
中科院分区：
文献类型：
--
作者：
Kampus, Priit;Kals, Jaak;Zilmer, Mihkel
目的衰老、血浆C反应蛋白（CRP）、氧化低密度脂蛋白（OxLDL）和同型半胱氨酸（Hcy）与动脉粥样硬化的发生有关。本研究的目的是评估年龄，炎症和氧化应激相关的标志物与动脉的功能和结构的变化在symptomaticpersons.Methods的关系，CRP，OxLDL和Hcy测定在175名临床健康受试者，年龄在40-70岁。结果OxLDL与IMT相关（r=0.24，P=0.003），CRP与AIx相关（r = 0.21，P=0.005）。Hcy与AIx及年龄校正IMT无相关性。AIx与年龄50岁有显著相关性（r=0.40; P=0.001）。在逐步回归分析中，年龄、体重、白色血细胞计数、OxLDL、心率和校正身高后的反射波形时间与IMT显著独立相关（R-2=0.41; P < 0.001）。以AIx为因变量，经逐步回归分析，AIx与年龄、性别、CRP、平均动脉压呈正相关，与心率、体重、身高呈负相关（R-2=0.63; P < 0.001）。结果表明，CRP和年轻的年龄与动脉硬化有关，而OxLDL和老年人成为无症状的动脉结构变化的更重要的决定因素。
Objective Ageing, plasma circulating C-reactive protein (CRP), oxidized low-density lipoprotein ( OxLDL) and homocysteine (Hcy) are associated with atherosclerosis. The aim of this study was to evaluate the relationship between age, inflammatory and oxidative stress-related markers with functional and structural changes of the arteries in asymptomatic persons.Methods CRP, OxLDL and Hcy were measured in 175 clinically healthy subjects, aged 40-70 years. Ultrasonography and pulse wave analysis were used to measure carotid intima-media thickness (IMT) and augmentation index (AIx).Results OxLDL was correlated with IMT (r=0.24, P=0.003), whereas CRP was correlated with AIx (r=0.21, P=0.005). No correlation was detected between Hcy and AIx or age-adjusted IMT. There was a significant association between AIx and age 50 years (r=0.40; P=0.001). In stepwise regression analysis age, weight, white blood cell count, OxLDL, heart rate and timing of the reflected waveform adjusted for height were significantly and independently associated with IMT (R-2=0.41; P < 0.001). At the same time, AIx as the dependent variable correlated positively with age, gender, CRP and mean arterial pressure, and negatively with heart rate, weight and height, in stepwise regression analysis (R-2=0.63; P < 0.001).Conclusion The results of the present study showed that CRP, OxLDL, Hcy and age are not similarly related to AIx and IMT in asymptomatic persons. The results suggest that CRP and younger age are related to arterial stiffness, whereas OxLDL and older age become more important determinants of structural changes of the arteries in asymptomatic