Cross-resistance relationships between neonicotinoids and pymetrozine in Bemisia tabaci (Hemiptera: Aleyrodidae)
Cross-resistance relationships between neonicotinoids and pymetrozine in Bemisia tabaci (Hemiptera: Aleyrodidae)
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DOI：
10.1002/ps.1989
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发表时间：
2010-11-01
影响因子：
4.1
通讯作者：
Denholm, Ian
中科院分区：
文献类型：
--
作者：
Gorman, Kevin;Slater, Russell;Denholm, Ian
背景：虽然同一杀虫剂组中化合物之间的交叉抗性是经常观察到的现象，但结构和功能特征不同的组之间的交叉抗性可能是极其不可预测的。在控制粉虱的情况下，烟粉虱属、新烟碱类和吡啶偶胺类拒食剂吡蚜酮代表了独立的发现线，应该适合交替使用，以避免对同一抗性机制进行长时间的选择。通过对7株烟粉虱的抗性分析和互补互选实验，研究了烟粉虱对新烟碱和吡蚜酮的抗性反应之间的关系。结果：所有菌株对噻虫嗪、吡虫啉和啶虫脒三种新烟碱类化合物的反应均表现出一致的相关性。6种田间菌株对新烟碱类杀虫剂的反应与吡蚜酮的反应明显相关。相互选择实验证实了一种意想不到的群体间交叉抗性。第七株表现出迄今为止独特的表型，对吡蚜酮有较强的抗性，但对新烟碱类完全敏感。选择实验证实该菌株对吡蚜酮的抗性机制是特异性的，对新烟碱类没有影响。结论：烟粉虱对新烟碱和吡蚜酮的交叉抗性可能反映了一种细胞色素- p450依赖的单加氧酶的过度表达，尽管它们的结构明显不同，但这种酶能够代谢这两种化合物。鉴于这一机制在烟粉虱中占主导地位，两者都有助于耐药性管理，但应置于同一处理“窗口期”。(C) 2010年化学工业学会
BACKGROUND: Although cross-resistance between compounds in the same insecticide group is a frequently observed phenomenon, cross-resistance between groups that differ in structural and functional characteristics can be extremely unpredictable. In the case of controlling the whitefly, Bemisia tabaci Gennadius, neonicotinoids and the pyridine azomethine antifeedant pymetrozine represent independent lines of discovery that should be suited for alternation to avoid prolonged selection for the same resistance mechanism. Reports of an association between responses to neonicotinoids and pymetrozine were investigated by resistance profiling of seven B. tabaci strains and complementary reciprocal selection experiments.RESULTS: All strains demonstrated a consistent correlation between responses to three neonicotinoid compounds: thiamethoxam, imidacloprid and acetamiprid. Responses to neonicotinoids for six field strains clearly correlated with responses to pymetrozine. Reciprocal selection experiments confirmed an unexpected case of intergroup cross-resistance. A seventh strain exhibited a so far unique phenotype of strong resistance to pymetrozine but full susceptibility to neonicotinoids. Selection experiments confirmed that in this strain the mechanism of pymetrozine resistance is specific and has no implications for neonicotinoids.CONCLUSION: Cross-resistance between neonicotinoids and pymetrozine in B. tabaci probably reflects the overexpression of a cytochrome-P450-dependent monooxygenase capable of metabolising both types of compound in spite of their apparent structural dissimilarity. Given the predominance of this mechanism in B. tabaci, both can contribute to resistance management but should be placed within the same treatment 'window'. (C) 2010 Society of Chemical Industry