Amyloid β deposition in subcortical stroke patients and effects of educational achievement: A pilot study
Amyloid β deposition in subcortical stroke patients and effects of educational achievement: A pilot study
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DOI：
10.1002/gps.5178
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发表时间：
2019-11
影响因子：
4
通讯作者：
F. Yasuno;K. Kajimoto;M. Ihara;A. Taguchi;Akihide Yamamoto;T. Fukuda;H. Kazui;H. Iida;K. Nagatsuka
中科院分区：
文献类型：
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作者：
F. Yasuno;K. Kajimoto;M. Ihara;A. Taguchi;Akihide Yamamoto;T. Fukuda;H. Kazui;H. Iida;K. Nagatsuka
脑血管危险因素/中风与淀粉样蛋白β(Aβ)沉积之间的直接因果关系尚未得到证实。我们对亚急性缺血性卒中患者和健康对照组进行了[11C]匹兹堡化合物B(PIB)正电子发射断层扫描(PET)分析。我们假设亚急性缺血性卒中患者将在皮质区域表现出局灶性Aβ积聚，在卒中发病后的慢性期，这种积聚会随着时间的推移而增加和延长。
A direct causal relationship of cerebrovascular risk factors/stroke to amyloid β (Aβ) deposition has yet to be shown. We conducted [11C] Pittsburgh compound B (PiB)–positron emission tomography (PET) analysis on subacute ischemic stroke patients and healthy controls. We hypothesized that subacute ischemic stroke patients would show focal Aβ accumulation in cortical regions, which would increase and extend over time during the chronic phase after stroke onset.