Decreased Intra- and Inter-Salience Network Functional Connectivity is Related to Trait Anxiety in Adolescents.
Decreased Intra- and Inter-Salience Network Functional Connectivity is Related to Trait Anxiety in Adolescents.
复制标题
显着网络内和显着网络间功能连接的减少与青少年的特质焦虑有关
DOI：
10.3389/fnbeh.2015.00350
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发表时间：
2015
影响因子：
3
通讯作者：
Gu R
中科院分区：
文献类型：
--
作者：
Geng H;Li X;Chen J;Li X;Gu R
目的：青少年是焦虑易感性的关键期。关注青少年焦虑易感性的影像学研究表明，边缘系统和执行控制系统之间的不同发展轨迹可能在这一现象中起重要作用。然而，很少有研究从功能网络的角度探讨这种易感性的大脑基础。突出网络（SN）由一系列参与焦虑发展的关键边缘和前额叶区域组成，如杏仁核、前岛（AI）和背前扣带皮层（dACC）。该系统中的网络内连接和网络间连接在自下而上的注意和自上而下的焦虑调节中起着至关重要的作用，然而，以网络为中心的连接是否与青少年的特质焦虑（即焦虑易感性）有关尚不清楚。方法：采用静息状态功能磁共振成像（fMRI）技术，以杏仁核、AI和dACC为感兴趣区（ROI），探讨青少年神经网络内和网络间功能连通性（FC）与特质焦虑的关系。结果：我们发现特质焦虑水平与SN中的特征性AI-dACC FC以及SN与多个功能系统（包括默认模式网络和执行控制网络）之间的分布式网络间FC呈负相关。结论：网络内和网络间FC的减弱与青少年特质焦虑的升高有关，这可能是显著性加工和认知调节改变的基础。
Objective: Adolescence is a critical period for the vulnerability of anxiety. Imaging studies focusing on adolescents' susceptibility to anxiety suggest that the different development trajectories between the limbic system and the executive control system may play important roles in this phenomenon. However, few studies have explored the brain basis of this susceptibility from the perspective of functional networks. The salience network (SN) consists of a series of key limbic and prefrontal regions that are engaged in the development of anxiety, such as the amygdala, anterior insula (AI), and dorsal anterior cingulate cortex (dACC). Intra- and inter-network connections in this system play essential roles in bottom-up attention and top-down regulation of anxiety, nevertheless, little is known about whether the SN-centered connections are associated with trait anxiety (i.e., susceptibility to anxiety) in adolescents. Method: Here, we applied resting-state functional magnetic resonance imaging (fMRI) to explore the relationship between intra- and inter-network functional connectivity (FC) of the SN and trait anxiety in adolescents using the amygdala, AI and dACC as the regions of interest (ROI). Results: We found that trait anxiety levels were inversely associated with both characteristic AI-dACC FC in the SN and distributed inter-network FC between the SN and multiple functional systems, which included the default mode network and the executive control network. Conclusions: Our results indicate that weaker intra- and inter-network FC of the SN was linked to higher trait anxiety among adolescents, and it may underlie altered salience processing and cognitive regulation.