A study of hepatocellular carcinoma using morphometric and densitometric image analysis.
A study of hepatocellular carcinoma using morphometric and densitometric image analysis.
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使用形态测量和密度测量图像分析进行肝细胞癌的研究。
DOI：
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发表时间：
1993
影响因子：
3.5
通讯作者：
A. Marchevsky
中科院分区：
文献类型：
--
作者：
B. Erler;H. Truong;S. S. Kim;M. H. Huh;S. Geller;A. Marchevsky
肝细胞癌通常难以在细胞学材料和活检标本中诊断。为了证明图像分析在区分良性和恶性肝细胞中的实用性，我们对42例肝细胞癌患者的苏木精和伊红染色的组织学切片进行了42个恶性细胞组和26个良性细胞组的比较，这些细胞组具有广泛的核形态。核测量使用相对便宜的基于微机的图像分析系统，使用高度灵活的成像软件包。评估了22个核形态和密度参数。核长轴是良恶性细胞的最佳单一鉴别器。利用优化的线性判别函数对检测样本进行分类，获得肝细胞癌阳性预测值（PV+）和阴性预测值（PV-）：主轴PV+ 95.0%, PV- 85.7%；5个密度参数分别为90.5% PV+和84.6% PV-；三个形态参数为100% PV+和86.7% PV-；9个形态/密度组合参数的PV+和PV-分别为95.5%和100%。这些结果表明，通过图像分析测量的核特征的多元线性判别函数可以准确地分类良恶性肝细胞。
Hepatocellular carcinoma is often difficult to diagnose in cytologic material and biopsy specimens. To demonstrate the utility of image analysis in discriminating benign and malignant hepatocytes, 42 malignant cell groups were compared with 26 benign cell groups with a wide range of nuclear morphology in hematoxylin and eosin-stained histologic sections from 42 patients with hepatocellular carcinoma. Nuclear measurements were performed with a relatively inexpensive microcomputer-based image analysis system using a highly flexible imaging software package. Twenty-two nuclear morphometric and densitometric parameters were evaluated. The best single discriminator of benign and malignant cells was the nuclear major axis. Classification of the test samples using optimized linear discriminant functions achieved the following positive predictive values (PV+) and negative predictive values (PV-) for hepatocellular carcinoma: 95.0% PV+ and 85.7% PV- for the major axis; 90.5% PV+ and 84.6% PV- for five densitometric parameters; 100% PV+ and 86.7% PV- for three morphometric parameters; and 95.5% PV+ and 100% PV- for nine combined morphometric/densitometric parameters. These results demonstrate that multivariate linear discriminant functions of nuclear features measured by image analysis can be used to classify benign and malignant hepatocytes accurately.
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流式细胞术诊断病理学的进展。
DOI：
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发表时间：
1987
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Coon,JS;Landay,AL;Weinstein,RS
通讯作者：
Weinstein,RS
定量细胞病理学和组织病理学中的图像分析。
影响因子：
3.3
作者：
Wied,GL;Bartels,PH;Bibbo,M;Dytch,HE
通讯作者：
Dytch,HE
影响因子：
3.5
作者：
A. Dawson;Austin Re;Weinberg Ds
通讯作者：
A. Dawson;Austin Re;Weinberg Ds
肝细胞发育不良和良性肝肿瘤的病理评估：与恶性肿瘤的鉴别。
影响因子：
2.3
作者：
Crawford,JM
通讯作者：
Crawford,JM