Season of birth and food-induced anaphylaxis in Boston.
Season of birth and food-induced anaphylaxis in Boston.
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DOI：
10.1111/j.1398-9995.2010.02384.x
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发表时间：
2010-11
期刊：
影响因子：
12.4
通讯作者：
Camargo CA Jr
中科院分区：
文献类型：
--
作者：
Vassallo MF;Banerji A;Rudders SA;Clark S;Camargo CA Jr
特应性疾病是世界范围内日益严重的问题。一些证据表明，紫外线B（UVB）、阳光照射和/或维生素D状态与特应性疾病有关，如哮喘（1）和特应性皮炎（2）。食物过敏的危险因素和发病机制的完整模型仍然难以捉摸。2007年，Camargo及其同事提出，在美国观察到肾上腺素自动注射器处方率存在强烈的南北梯度后，维生素D状态可能会影响食物诱导的过敏反应（FIA）的风险（3）。由于UVB暴露和维生素D状态与高纬度地区的季节密切相关（4），在秋末和冬季观察到两者的最低水平，我们假设波士顿FIA患者的比例更高出生在秋季和冬季。为了检验这一假设，我们调查了（i）出生季节是否可能与FIA的风险在一个广泛的患者群体和（ii）如果这样的关联被确定，它会因年龄而异。
Atopic diseases are a growing problem worldwide. Several lines of evidence link ultraviolet light B (UVB) sunlight exposure and/or vitamin D status to atopic disorders, such as asthma (1) and atopic dermatitis (2). A complete model of the risk factors and pathogenesis of food allergy remains elusive. In 2007, Camargo and colleagues proposed that vitamin D status might influence risk of food-induced anaphylaxis (FIA) after observing a strong north–south gradient in epinephrine autoinjector prescription rates in the United States (3). Because UVB exposure and vitamin D status are strongly related to season at higher latitudes (4), with lowest levels of both observed during the late fall and winter seasons, we hypothesized that a higher percentage of Boston patients with FIA would be born in the fall and winter seasons. To examine this hypothesis, we investigated (i) whether season of birth might be associated with risk of FIA in a broad group of patients and (ii) if such an association was identified, would it differ by age.