The roles of MASPIN expression and subcellular localization in non-small cell lung cancer
The roles of MASPIN expression and subcellular localization in non-small cell lung cancer
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DOI：
10.1042/bsr20200743
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发表时间：
2020-05-26
影响因子：
4
通讯作者：
Zhu, Ye-Han
中科院分区：
文献类型：
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作者：
Wang, Xiao-Fei;Liang, Bo;Zhu, Ye-Han
越来越多的研究证实，乳腺癌丝氨酸蛋白酶抑制物(MASPIN)在非小细胞肺癌(NSCLC)中起重要作用。然而，结果仍然存在争议或不一致。在本研究中，我们试图确定MASPIN在非小细胞肺癌中的临床意义及其潜在的分子作用。Meta分析MASPIN与预后和临床病理特征的相关性。此外，还通过几个在线数据库对MASPIN在非小细胞肺癌中的潜在分子机制进行了研究。12篇高质量研究共纳入2220例NSCLC患者，结果表明MASPIN胞核和胞浆表达上调与总生存率(OS)相关(危险性比(HR)=1.43，95%可信区间(CI)=1.01~2.04，P
Accumulating studies have confirmed that mammary serine protease inhibitor (MASPIN) plays an essential role in non-small cell lung cancer (NSCLC). However, results are still controversial or inconsistent. In the present study, we attempted to identify the clinical significance of MASPIN and its potential molecular roles in NSCLC. The correlation of MASPIN with prognosis and clinicopathological characteristics was assessed by meta-analysis. Additionally, the potential molecular mechanisms of MASPIN in NSCLC was also investigated through several online databases. A total of 2220 NSCLC patients from 12 high quality studies were included and the results indicated that up-regulated MASPIN nucleus and cytoplasm expression was associated with poor overall survival (OS) (hazard ratio (HR) = 1.43, 95% confidence interval (CI) = 1.01-2.04, P