Cardiovascular Toxicity of Citrus aurantium in Exercised Rats
Cardiovascular Toxicity of Citrus aurantium in Exercised Rats
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DOI：
10.1007/s12012-013-9199-x
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发表时间：
2013-09-01
影响因子：
3.2
通讯作者：
Fabricant, Daniel
中科院分区：
文献类型：
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作者：
Hansen, Deborah K.;George, Nysia I.;Fabricant, Daniel
当安全问题迫使麻黄从市场上下架时，其他植物药物，包括柑橘或苦橙(BO)被用作替代品。BO提取物的主要成分是辛弗林，这是一种结构类似麻黄素的化学物质。由于麻黄素具有心血管作用，在运动过程中可能会加剧，因此本研究的目的是确定含有辛弗林的提取物是否对运动大鼠的心血管系统产生不利影响。SD大鼠每天灌胃给予10或50毫克/公斤体重的辛弗林，从两种不同的提取物中选择一种；咖啡因加入一些剂量。大鼠在跑步机上跑30分钟/天，每周3天。监测心率、血压、体温和QT间期。两种剂量的提取物在给药后8小时内都能显著提高收缩压和舒张压。对心率和体温的影响似乎主要是由于咖啡因的影响。这些数据表明，辛弗林、咖啡因和运动的组合可以对血压有显著影响，但似乎在减少食物消耗或体重方面并不有效。
When safety concerns forced the removal of ephedra from the market, other botanicals, including Citrus aurantium or bitter orange (BO) were used as replacements. A major component of the BO extract is synephrine, a chemical that is structurally similar to ephedrine. Because ephedrine has cardiovascular effects that may be exacerbated during physical exercise, the purpose of this study was to determine whether extracts containing synephrine produced adverse effects on the cardiovascular system in exercising rats. Sprague-Dawley rats were dosed daily by gavage for 28 days with 10 or 50 mg of synephrine/kg body weight from one of two different extracts; caffeine was added to some doses. The rats ran on a treadmill for 30 min/day, 3 days/week. Heart rate, blood pressure, body temperature, and QT interval were monitored. Both doses of both extracts significantly increased systolic and diastolic blood pressure for up to 8 h after dosing. Effects on heart rate and body temperature appeared to be due primarily to the effects of caffeine. These data suggest that the combination of synephrine, caffeine, and exercise can have significant effects on blood pressure and do not appear to be effective in decreasing food consumption or body weight.