Novel vaccine strategies against emerging viruses
Novel vaccine strategies against emerging viruses
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DOI：
10.1016/j.coviro.2013.02.001
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发表时间：
2013-04-01
影响因子：
5.9
通讯作者：
Mena, Ignacio
中科院分区：
文献类型：
--
作者：
Garcia-Sastre, Adolfo;Mena, Ignacio
新出现的病毒的主要公共卫生问题之一是它们可能被引入免疫幼稚的易感宿主群体并在其中持续传播。通过接种疫苗诱导保护性免疫力，可以通过向高危人群提供保护，成为预防这一问题的有力工具。开发针对新出现病原体的疫苗的常规方法具有显著的局限性：缺乏针对几种新出现的关注病毒的实验工具、免疫原性差、安全性问题或缺乏针对抗原变体的交叉保护。未来病毒威胁出现的不可预测性要求有能力快速开发安全，有效的vaccine.We描述了一些新的疫苗策略，正在探索作为替代经典的减毒和灭活疫苗的最新进展，并提供新出现的病毒潜在的新型疫苗的例子。这些方法可能适用于控制许多其他新出现的病原体。
One of the main public health concerns of emerging viruses is their potential introduction into and sustained circulation among populations of immunologically naive, susceptible hosts. The induction of protective immunity through vaccination can be a powerful tool to prevent this concern by conferring protection to the population at risk. Conventional approaches to develop vaccines against emerging pathogens have significant limitations: lack of experimental tools for several emerging viruses of concern, poor immunogenicity, safety issues, or lack of cross-protection against antigenic variants. The unpredictability of the emergence of future virus threats demands the capability to rapidly develop safe, effective vaccines.We describe some recent advances in new vaccine strategies that are being explored as alternatives to classical attenuated and inactivated vaccines, and provide examples of potential novel vaccines for emerging viruses. These approaches might be applied to the control of many other emerging pathogens.