Injectable biodegradable hydrogels: progress and challenges
Injectable biodegradable hydrogels: progress and challenges
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DOI：
10.1039/c3tb20940g
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发表时间：
2013-01-01
影响因子：
7
通讯作者：
Kurisawa, Motoichi
中科院分区：
文献类型：
--
作者：
Bae, Ki Hyun;Wang, Li-Shan;Kurisawa, Motoichi
在过去的几十年里，可注射水凝胶因其生物相容性、良好的渗透性、最小的创伤以及易于整合到外科手术中而成为一种有前途的生物材料。这些系统提供了一种有效和方便的方法来管理各种生物活性物质，如蛋白质、基因，甚至活细胞。此外，它们可以被设计为可降解，并在完成任务后最终从体内清除。由于其独特的特性，可注射生物降解性水凝胶已被积极探索作为药物储存系统，用于组织工程中生物活性物质和临时细胞外基质的持续释放。本文综述了构建合理设计的可注射生物可降解水凝胶用于蛋白质、药物输送和组织工程的最新策略。我们还讨论了可注射水凝胶在基因传递系统和生物医学粘合剂中的应用。
Over the past decades, injectable hydrogels have emerged as promising biomaterials because of their biocompatibility, excellent permeability, minimal invasion, and easy integration into surgical procedures. These systems provide an effective and convenient way to administer a wide variety of bioactive agents such as proteins, genes, and even living cells. Additionally, they can be designed to be degradable and eventually cleared from the body after completing their missions. Given their unique characteristics, injectable biodegradable hydrogels have been actively explored as drug reservoir systems for sustained release of bioactive agents and temporary extracellular matrices for tissue engineering. This review provides an overview of state-of-the-art strategies towards constructing a rational design of injectable biodegradable hydrogels for protein drug delivery and tissue engineering. We also discuss the use of injectable hydrogels for gene delivery systems and biomedical adhesives.