Age and gender effects on the extent of myocardial involvement in acute myocarditis: a cardiovascular magnetic resonance study
Age and gender effects on the extent of myocardial involvement in acute myocarditis: a cardiovascular magnetic resonance study
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DOI：
10.1136/hrt.2008.164061
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发表时间：
2009-12-01
期刊：
影响因子：
5.7
通讯作者：
Friedrich, M. G.
中科院分区：
文献类型：
--
作者：
Cocker, M. S.;Abdel-Aty, H.;Friedrich, M. G.
目的：根据流行病学研究，男性和低龄是发生致死性心肌炎的危险因素。然而，年龄和性别对急性心肌炎心肌损伤模式的影响尚不清楚。在临床急性心肌炎患者中，这项研究试图通过心血管磁共振(CMR)成像来表征患者年龄、性别和心肌受累程度之间的关系。设计、地点和患者：65例临床急性心肌炎患者(42岁，SD 15，男性41例)。使用标准方法，获得T2加权和对比增强的T1加权(早期和晚期增强)CMR图像。T2图像在视觉上和定量上评估是否有水肿。早期增强图像对炎症进行了量化，晚期增强图像也对局部纤维化进行了量化。分析了不同年龄段(40岁，
Objective: Based upon epidemiological studies, male gender and younger age are risk factors for developing fatal myocarditis. The impact of age and gender on myocardial injury pattern in acute myocarditis, however, is not well understood. In patients with clinically acute myocarditis, this study sought to characterise the relation between patient age and gender and the extent of myocardial involvement using cardiovascular magnetic resonance (CMR) imaging. CMR markers for oedema, inflammation and fibrosis defined myocardial involvement.Design, Setting and Patients: 65 patients (42 years old (SD 15), 41 male) with clinically acute myocarditis were assessed. Using standard methods, T2-weighted and contrast-enhanced T1-weighted (early and late enhancement) CMR images were acquired. T2 images were visually and quantitatively assessed for oedema. Early enhancement images were quantified for inflammation, as was regional fibrosis in late enhancement images. Data were analysed for groups of age (>40,