Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition.
Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition.
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DOI：
10.1155/2015/654765
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发表时间：
2015
影响因子：
--
通讯作者：
Prince S
中科院分区：
文献类型：
--
作者：
Järvinen TA;Prince S
Decorin （DCN）是存在于结缔组织中的细胞外富含亮氨酸的小蛋白聚糖家族中最具特征的成员，通常与胶原原纤维相关或“修饰”胶原原纤维。它具有抗纤维化、抗炎、抗癌的作用，在临床医学中具有重要的应用价值。对DCN敲除小鼠的研究已经证实，缺乏DCN有利于肿瘤的发展，它被认为是一种肿瘤抑制基因。据报道，在各种形式的人类癌症的肿瘤进展过程中，DCN的表达减少或完全消失。此外，当用作治疗分子时，DCN在实验癌症模型中已显示出抑制肿瘤进展和转移的作用。DCN通过靶向一些参与细胞生长、存活、转移和血管生成的关键信号分子来影响各种类型癌症的生物学。中和不同生长因子的活性位点都位于DCN分子的不同部位。一个新兴的概念是，多种蛋白酶，特别是由炎症细胞产生的蛋白酶，能够切割DCN，这表明天然DCN可能在许多病理性炎症条件下失活。本文就DCN在肿瘤中的作用作一综述。
Decorin (DCN) is the best characterized member of the extracellular small leucine-rich proteoglycan family present in connective tissues, typically in association with or “decorating” collagen fibrils. It has substantial interest to clinical medicine owing to its antifibrotic, anti-inflammatory, and anticancer effects. Studies on DCN knockout mice have established that a lack of DCN is permissive for tumor development and it is regarded as a tumor suppressor gene. A reduced expression or a total disappearance of DCN has been reported to take place in various forms of human cancers during tumor progression. Furthermore, when used as a therapeutic molecule, DCN has been shown to inhibit tumor progression and metastases in experimental cancer models. DCN affects the biology of various types of cancer by targeting a number of crucial signaling molecules involved in cell growth, survival, metastasis, and angiogenesis. The active sites for the neutralization of different growth factors all reside in different parts of the DCN molecule. An emerging concept that multiple proteases, especially those produced by inflammatory cells, are capable of cleaving DCN suggests that native DCN could be inactivated in a number of pathological inflammatory conditions. In this paper, we review the role of DCN in cancer.