Predictive value of nuclear factor κB activity and plasma cytokine levels in patients with sepsis
Predictive value of nuclear factor κB activity and plasma cytokine levels in patients with sepsis
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DOI：
10.1128/iai.68.4.1942-1945.2000
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发表时间：
2000-04-01
影响因子：
3.1
通讯作者：
Montiel, C
中科院分区：
文献类型：
--
作者：
Arnalich, F;Garcia-Palomero, E;Montiel, C
血浆中细胞因子浓度波动与脓毒症结果之间的关系很复杂。我们推测，早期测量核因子 kappa B (NF-kappa B)（一种参与促炎细胞因子表达的转录调节蛋白）的激活可能有助于预测脓毒症的结果。我们测定了 34 名严重脓毒症患者（23 名幸存者和 11 名非幸存者）外周血单核细胞中 NF-κ B 的激活情况以及血浆中炎症细胞因子（白细胞介素 6、白细胞介素 1 和肿瘤坏死因子）和各种内源性拮抗剂的系列浓度。 NF-kappa B 活性在非幸存者中显着较高，并且与疾病的严重程度（APACHE II 评分）密切相关，尽管两者都与细胞因子水平无关。除了 NF-kappa B 活性外，白细胞介素 1 受体拮抗剂是唯一测试的细胞因子，其血浆水平对预测死亡率具有逻辑回归分析的价值。这些结果强调了早期测量 NF-κ B 活性对严重脓毒症患者的预后价值。
The relationship between fluctuating cytokine concentrations in plasma and the outcome of sepsis is complex. We postulated that early measurement of the activation of nuclear factor kappa B (NF-kappa B), a transcriptional regulatory protein involved in proinflammatory cytokine expression, may help to predict the outcome of sepsis. We determined NF-kappa B activation in peripheral blood mononuclear cells of 34 patients with severe sepsis (23 survivors and 11 nonsurvivors) and serial concentrations of inflammatory cytokines (interleukin-6, interleukin-1, and tumor necrosis factor) and various endogenous antagonists in plasma. NF-kappa B activity was significantly higher in nonsurvivors and correlated strongly with the severity of illness (APACHE II score), although neither was related to the cytokine levels, Apart from NF-kappa B activity, the interleukin-1 receptor antagonist was the only cytokine tested whose level in plasma was of value in predicting mortality bs logistic regression analysis. These results underscore the prognostic value of early measurement of NF-kappa B activity in patients with severe sepsis.