Antiphosphatidylethanolamine antibody as the sole antiphospholipid antibody in systemic lupus erythematosus with thrombosis.
Antiphosphatidylethanolamine antibody as the sole antiphospholipid antibody in systemic lupus erythematosus with thrombosis.
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抗磷脂酰乙醇胺抗体是系统性红斑狼疮伴血栓形成中唯一的抗磷脂抗体。
DOI：
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发表时间：
1992
影响因子：
3.7
通讯作者：
M. Boffa
中科院分区：
文献类型：
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作者：
M. Karmochkine;Patrice Cacoub;J. Piette;Pierre Godeau;M. Boffa
一名以前健康的34岁女性，被诊断为系统性红斑狼疮（SLE），膜性肾小球病，迅速改善。在她的血浆中既没有检测到狼疮抗凝剂也没有检测到抗心磷脂抗体。经过三个月的完全缓解，她发展为严重的肺血栓栓塞症，没有发现具体的生物学原因。她的血浆分析不同的抗磷脂抗体：狼疮抗凝剂和抗心磷脂抗体再次阴性。使用用五种不同的阴离子磷脂或两性离子磷脂酰乙醇胺制备的ELISA，在她的血浆中仅发现抗磷脂酰乙醇胺IgG。在狼疮患者中，抗磷脂抗体的存在现在被公认为是反复血栓形成和/或复发性流产的高危因素。这种情况下，抗磷脂酰乙醇胺抗体的存在下，应调查的原因不明的血栓形成的SLE，在通常的临床和生物学研究未能阐明。
A previously healthy 34-year-old woman, was diagnosed as having systemic lupus erythematosus (SLE), with membranous glomerulopathy which improved rapidly. Neither lupus anticoagulant nor anticardiolipin antibodies were detected in her plasma. After three months of total remission, she developed a severe pulmonary thromboembolism for which no specific biological cause was found. Her plasma was analysed for different antiphospholipid antibodies: lupus anticoagulant and anticardiolipin antibodies were again negative. Using an ELISA prepared with either five different anionic phospholipids or zwitterionic phosphatidylethanolamine, solely an anti-phosphatidylethanolamine IgG was discovered in her plasma. In lupus patients, the presence of antiphospholipid antibodies is now well recognized as a high risk factor for repeated thrombosis and/or recurrent abortions. This case suggests that the presence of antiphosphatidylethanolamine antibody should be investigated in cases of unexplained thrombosis in SLE, where the usual clinical and biological investigations have failed to shed light.