HOST RESPONSES IN PERIODONTAL-DISEASES
HOST RESPONSES IN PERIODONTAL-DISEASES
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DOI：
10.1177/00220345840630031601
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发表时间：
1984-01-01
影响因子：
7.6
通讯作者：
SLOTS, J
中科院分区：
文献类型：
--
作者：
GENCO, RJ;SLOTS, J
在过去的二十年中，我们对宿主反应的理解有了显著的进展，宿主反应在决定牙周感染的过程中起着关键作用。我们已经了解了与牙周疾病相关的微生物群，并且在某种程度上，一些可以破坏牙周组织的特定细菌种类已经被识别和表征。本文综述了在牙周病病因学中起重要作用的革兰氏阴性细菌的研究进展。例如，在许多成人牙周炎病例中，牙龈拟杆菌（Bacteroides gingivalis）似乎是一个主要的病原微生物，放线菌（放线菌）在局部青少年牙周炎中，中间拟杆菌和中等大小的螺旋体在急性坏死性溃疡性牙龈炎中。在青少年糖尿病患者、粒细胞减少和免疫功能低下的宿主中，碳吞噬菌与晚期牙周炎有关，而中间拟杆菌与妊娠牙龈炎有关。其他生物，如真杆菌种、嗜血杆菌种、Wolinella种、梭杆菌种、脓硒单胞菌和腐蚀艾肯氏菌，似乎也参与一些破坏性牙周病患者。本论文将强调宿主对牙周病细菌的免疫反应的特征，这些反应限制了这些细菌在宿主体内定植、在牙龈袋中存活以及侵入牙龈和邻近组织的能力。对牙周病细菌的免疫反应的其他特征导致结缔组织、牙槽骨和牙齿周围的其他组织成分的破坏，这些也将被介绍。免疫反应在纤维化和愈合过程中的作用——这一过程经常发生在牙周组织主动破坏之后，甚至在牙周组织主动破坏的情况下——将被讨论。
There have been marked advances in the past two decades in our understanding of host responses which play a critical role in determining the course of periodontal infections. We have knowledge of the microflora associated with periodontal diseases, and, to some extent, some of the specific bacterial species which can destroy periodontal tissues have been identified and characterized. In the accompanying paperl, studies of specific gram-negative bacteria which play a major role in the etiology of periodontal disease are reviewed. For example, Bacteroides gingivalis appears to be a major etiologic organism in many cases of adult periodontitis, Actinobacillus actinomycetemcomitans (Aa) in localized juvenile periodontitis, and Bacteroides intermedius and intermediate-sized spirochetes in acute necrotizing ulcerative gingivitis. Capnocytophaga species have been associated with advanced periodontitis in juvenile diabetics and in granulocytopenic and immunocompromised hosts, whereas Bacteroides intermedius has been associated with pregnancy gingivitis. Other organisms such as Eubacterium species, Haemophilus species, Wolinella species, Fusobacterium species, Selenomonas sputigena, and Eikenella corrodens appear also to participate in some patients with destructive periodontal disease. 1The present paper will emphasize characteristics of the host's immune response to periodontopathic bacteria which act to limit the ability of these bacteria to colonize the host, to survive in the gingival pocket, and to invade the gingiva and adjacent tissues. Other features of the immune response to periodontopathic bacterialead to destruction of the connective tissues, alveolar bone, and other tissue components surrounding the tooth and will also be presented. The role of the immune response in fibrosis and healing-processes which often occur following, or even in the presence of, active periodontal tissue destruction-will be discussed.