Effects of cardiac resynchronization therapy on left ventricular remodeling and dyssynchrony in patients with left ventricular noncompaction and heart failure
Effects of cardiac resynchronization therapy on left ventricular remodeling and dyssynchrony in patients with left ventricular noncompaction and heart failure
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心脏再同步治疗对左心室致密化不全心力衰竭患者左心室重构和不同步的影响
DOI：
10.1007/s10554-014-0568-8
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Wang JF
中科院分区：
文献类型：
--
作者：
Qiu Q;Chen YX;Mai JT;Yuan WL;Wei YL;Liu YM;Yang L;Wang JF
Left ventricular noncompaction (LVNC) is a rare cardiomyopathy with high incidence of heart failure (HF). It is unclear whether LVNC patients with desynchronized HF would benefit from cardiac resynchronization therapy (CRT). In order to evaluate the effect of CRT on LVNC, this study explored left ventricular (LV) remodeling and mechanical synchronicity before and after CRT in LVNC patients, and compare with that in idiopathic dilated cardiomyopathy (DCM) patients. We collected 15 LVNC and 30 matched DCM patients. All the patients underwent clinical evaluation,electrocardiogram and echocardiography before CRT and ≥6 months later. LV response was defined as ≥15 % decrease in LV end-systolic volume (LVESV). Longitudinal synchronicity was quantified by YU-index using tissue Doppler imaging. The time delay of peak radial strain from anteroseptal to posterior wall, which derived from speckle tracking imaging, was used to quantify radial synchronicity. In LVNC group, LV ejection fraction increased from 27.6 ± 5.5 to 39.1 ± 7.0 % (P< 0.01) during follow-up, but LV volumes did not change significantly (bothP> 0.05). Five LVNC patients (33.3 %) responded to CRT, and all of them were super-responders (reduction in LVESV > 30 %). In addition, the number of noncompacted segments and the thickness ratio of noncompacted to compacted myocardium decreased (bothP< 0.05). Inter-ventricular, longitudinal and radial intra-ventricular dyssynchrony also reduced significantly (allP< 0.05). Compared with DCM group, there was no significant difference in LV response rate (33.3 vs. 60.0 %,P= 0.092), improvement of LV function and dyssynchrony index (allP< 0.05). In conclusion, CRT improved heart function, morphology and mechanical dyssynchrony in LVNC patients.
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影响因子：
6
作者：
D. Penela;B. Bijnens;A. Doltra;Etelvino Silva;M. Castel;A. Berruezo;L. Mont;F. Weidemann;J. Brugada;M. Sitges
通讯作者：
D. Penela;B. Bijnens;A. Doltra;Etelvino Silva;M. Castel;A. Berruezo;L. Mont;F. Weidemann;J. Brugada;M. Sitges
影响因子：
5.5
作者：
Daubert, Jean-Claude;Saxon, Leslie;Zamorano, Jose Luis
通讯作者：
Zamorano, Jose Luis
影响因子：
20.1
作者：
Kirk JA;Kass DA
通讯作者：
Kass DA
影响因子：
5
作者：
K. Wasmer;J. Köbe;D. Andresen;R. Zahn;S. Spitzer;J. Jehle;J. Brachmann;C. Stellbrink;Eimo Martens;M. Hochadel;J. Senges;H. Klein;L. Eckardt
通讯作者：
K. Wasmer;J. Köbe;D. Andresen;R. Zahn;S. Spitzer;J. Jehle;J. Brachmann;C. Stellbrink;Eimo Martens;M. Hochadel;J. Senges;H. Klein;L. Eckardt
DOI：
10.1016/j.ycar.2012.02.064
发表时间：
2012
期刊：
Yearbook of Cardiology
影响因子：
--
作者：
M. Gold
通讯作者：
M. Gold