Treatment of posttraumatic olfactory dysfunction with corticosteroids and olfactory training
Treatment of posttraumatic olfactory dysfunction with corticosteroids and olfactory training
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DOI：
10.1080/00016489.2020.1767301
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发表时间：
2020-05-30
影响因子：
1.4
通讯作者：
Skandsen, Toril
中科院分区：
文献类型：
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作者：
Bratt, Mette;Moen, Kent G.;Skandsen, Toril
背景：很少有人研究治疗创伤后嗅觉功能障碍（OD）的长期效果。目的/目标：探讨皮质类固醇序贯治疗和嗅觉训练 (OT) 是否可以改善中度和重度创伤性脑损伤 (TBI) 后 OD 患者的嗅觉。材料和方法：22 名持续性 OD 患者（平均在创伤后 62 个月）完成了一项开放式非对照干预研究，即口服皮质类固醇治疗 10 天，然后每天两次 OT 治疗 3 个月。嗅觉通过嗅探棒进行评估。他们在四个时间点进行了测试，最后一次评估是在基线测量后 12 个月。结果：创伤时的平均年龄为 45 (SD 14) 岁。基线时的平均阈值、辨别和识别 (TDI) 评分为 14.4 (SD 7.3)，1 年后增加至平均值 20.8 (SD 7.4)（最低 -3.0；最高 19.5，p 值 = 6.0 TDI 分。基线时的改善与任何社会人口统计学或创伤相关特征或嗅觉功能无关。结论和意义：皮质类固醇和 OT 治疗有希望TBI 后持续性 OD 的发生率应进一步研究。
Background:Few have investigated long-term effect of treatment of posttraumatic olfactory dysfunction (OD). Aims/objectives:To explore if sequential treatment with corticosteroids and olfactory training (OT) improved smell in patients with OD after moderate and severe traumatic brain injury (TBI). Material and methods:Twenty-two patients with persistent OD, mean 62 months after trauma, completed an open uncontrolled intervention study of treatment for 10 d with oral corticosteroids and thereafter for 3 months with OT twice daily. Olfaction was assessed by Sniffin' Sticks. They were tested at four-time points, with the last assessment 12 months after baseline measurements. Results:Mean age at trauma was 45 (SD 14) years. Mean threshold, discrimination and identification (TDI) score at baseline was 14.4 (SD 7.3) and increased to mean 20.8 (SD 7.4) after 1 year (minimum -3.0; maximum 19.5,pvalue = 6.0 TDI points. Improvement was not associated with any sociodemographic or trauma-related characteristics or with olfactory function at baseline. Conclusions and significance:Treatment with corticosteroids and OT was promising in persistent OD after TBI and should be further studied.