Synthesis of fused polycyclic aromatics by palladium-catalyzed annulation of arynes using 2-halobiaryls
Synthesis of fused polycyclic aromatics by palladium-catalyzed annulation of arynes using 2-halobiaryls
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DOI：
10.1021/ja055781o
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发表时间：
2005-11-16
影响因子：
15
通讯作者：
Larock, RC
中科院分区：
文献类型：
--
作者：
Liu, ZJ;Zhang, XX;Larock, RC
钯催化的2-卤代联芳基和相关的乙烯基卤化物的芳炔的环化提供了非常有效、高产率的多环芳烃和杂芳烃的合成。这个过程似乎涉及催化，逐步耦合的两个非常反应性的基板，芳炔和有机钯物种，以产生良好的交叉耦合产品的产量。
The Pd-catalyzed annulation of arynes by 2-halobiaryls and related vinylic halides provides a very efficient, high yielding synthesis of polycyclic aromatic and heteroaromatic hydrocarbons. This process appears to involve the catalytic, stepwise coupling of two very reactive substrates, an aryne and an organopalladium species, to generate excellent yields of cross-coupled products.