Associations Between the 2D:4D Proxy Biomarker for Prenatal Hormone Exposures and Symptoms of Developmental Language Disorder.
Associations Between the 2D:4D Proxy Biomarker for Prenatal Hormone Exposures and Symptoms of Developmental Language Disorder.
复制标题
产前激素暴露的 2D:4D 代理生物标志物与发育性语言障碍症状之间的关联。
DOI：
10.1044/2017_jslhr-l-17-0143
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Ash,AndreaC
中科院分区：
文献类型：
--
作者：
Redmond,SeanM;Ash,AndreaC
PurposeRelative lengths of the index (2D) and ring (4D) fingers in humans represent a retrospective biomarker of prenatal hormonal exposures. For this reason, the 2D:4D digit ratio can be used to investigate potential hormonal contributions to the etiology of neurodevelopmental disorders. This study tested potential group differences in 2D:4D digit ratios in a sample of boys with and without developmental language disorder (DLD) and examined the strength of associations between 2D:4D digit ratio and a battery of verbal and nonverbal measures.MethodA group of 29 boys affected by DLD and a group of 76 boys with typical language abilities participated (age range = 5;6–11;0 years). Scanned images were used to measure finger lengths. Language measures included the core language subtests from the Clinical Evaluation of Language Fundamentals–Fourth Edition (Semel, Wiig, & Secord, 2003), a nonword repetition task, a sentence recall task, and the Test of Early Grammatical Impairment (Rice & Wexler, 2001).ResultsSignificant group differences indicated lower 2D:4D digit ratios in the group with DLD. Modest associations were found between 2D:4D digit ratios and some Clinical Evaluation of Language Fundamentals–Fourth Edition subtests.ConclusionsPrenatal hormone exposures may play a role in the etiology of some language symptoms.
