Mephedrone, Methylone and 3,4-Methylenedioxypyrovalerone (MDPV) Induce Conditioned Place Preference in Mice
Mephedrone, Methylone and 3,4-Methylenedioxypyrovalerone (MDPV) Induce Conditioned Place Preference in Mice
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DOI：
10.1111/bcpt.12253
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发表时间：
2014-11-01
影响因子：
3.1
通讯作者：
Kugelberg, Fredrik C.
中科院分区：
文献类型：
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作者：
Karlsson, Louise;Andersson, Mikael;Kugelberg, Fredrik C.
在过去十年中，合成卡西酮在世界范围内的流行和滥用有所增加。所谓的浴盐的常见成分包括甲氧麻黄酮、甲基one和3,4-亚甲基二氧基戊酮（MDPV）。关于这些药物的药理学和成瘾性的信息相对较少。我们使用条件位置偏好（CPP）范式探讨了三种不同的合成卡西酮的强化效应。本研究的主要目的是探讨甲氧麻黄酮、甲基酮和MDPV是否会诱导小鼠CPP。次要目的是研究可能的剂量-反应CPP，以及在相同剂量下合成卡西酮是否比安非他明诱导更高的CPP。C57BL/6小鼠分别给予0.5、2、5、10、20mg/kg （i.p）剂量的甲氧麻黄酮、甲酮、MDPV和安非他明。在调节期间，小鼠每天接受两次训练，连续4天。与对照组相比，所有四种测试药物都显示出显著的位置偏好。与安非他明（5和10mg/kg）组相比，MDPV（5和10mg/kg）组小鼠表现出更高的偏好得分。我们的研究结果表明，甲氧麻黄酮、甲基酮和MDPV产生的CPP等于或高于安非他明，这强烈表明它们具有成瘾性。鉴于滥用的公共卫生问题，未来的药理学研究是必要的，以充分了解这些药物的影响。
During the last decade, there has been a worldwide increase in popularity and abuse of synthetic cathinones. Common ingredients of the so-called bath salts include mephedrone, methylone and 3,4-methylenedioxypyrovalerone (MDPV). Relatively little information about the pharmacology and addiction potential of these drugs is available. We used the conditioned place preference (CPP) paradigm to explore the reinforcing effects of three different synthetic cathinones. The primary aim of this study was to investigate whether mephedrone, methylone and MDPV induce CPP in mice. The secondary aims were to investigate a possible dose-response CPP and whether the synthetic cathinones induce higher CPP than amphetamine at equal dose. C57BL/6 mice were conditioned to mephedrone, methylone, MDPV and amphetamine at doses of 0.5, 2, 5, 10 or 20mg/kg (i.p.). During the conditioning, the mice received two training sessions per day for 4days. All four tested drugs showed a significant place preference compared with controls. Mice conditioned with MDPV (5 and 10mg/kg) displayed a greater preference score compared to mice conditioned with amphetamine (5 and 10mg/kg). Our findings show that mephedrone, methylone and MDPV produce CPP equal or higher than amphetamine strongly suggesting addictive properties. Given the public health concern of abuse, future pharmacological studies are necessary to fully understand the effects of these drugs.