Human Papillomavirus Infection in Lung and Esophageal Cancers: Analysis of 485 Asian Cases
Human Papillomavirus Infection in Lung and Esophageal Cancers: Analysis of 485 Asian Cases
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DOI：
10.1002/jmv.22150
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发表时间：
2011-08-01
影响因子：
12.7
通讯作者：
Fukayama, Masashi
中科院分区：
文献类型：
--
作者：
Goto, Akiteru;Li, Chih-Ping;Fukayama, Masashi
人乳头瘤病毒（HPV）在肺癌和食管癌发展中的作用仍然没有定论，这与HPV在子宫颈癌发展中的既定作用相反。其中一个原因是这些癌症中报告的HPV感染率之间的差异。对亚洲8个机构（日本东京、高知、鹿儿岛和冲绳;韩国首尔和大邱;中华民国（台湾）昌化;新加坡和新加坡）的485例肺癌和食管癌（176例肺鳞状细胞癌，128例肺腺癌，181例食管癌）进行分析，以阐明HPV感染率。在日本东京大学病理学系的一个实验室中使用聚合酶链反应和原位杂交（ISH）的组合检查样本，以避免实验室间变异。HPV在肺鳞癌、肺腺癌和食管癌患者中的检出率分别为6.3%、7%和9.4%。在调查的地理区域中，鹿儿岛在食管癌病例中表现出显着较高的HPV感染率（24.1%）。肺癌中HPV感染率无地理差异。还进行了亚型特异性ISH，在大多数（75.7%）HPV阳性的肺癌和食管癌患者中鉴定出高危型HPV 16/18。医学病毒学杂志83：1383-1390，2011. (C)2011 Wiley-Liss，Inc.
The role of human papillomavirus (HPV) in the development of lung and esophageal cancer remains inconclusive, which is in contrast to the established role HPV plays in the development of uterine cervical cancer. One of the reasons for this is the difference among reported HPV infection rates in these cancers. An analysis of 485 lung and esophageal cancers (176 lung squamous cell carcinoma, 128 lung adenocarcinoma, 181 esophageal carcinoma) in eight institutions in Asia (Tokyo, Kochi, Kagoshima, and Okinawa, Japan; Seoul and Daegu, Korea; Changhua, Republic of China (Taiwan); Singapore, Singapore) was carried out in order to clarify infection rates with HPV. Samples were examined in one laboratory of the Department of Pathology, the University of Tokyo, Japan in order to avoid inter-laboratory variation using a combination of polymerase chain reaction and in situ hybridization (ISH). HPV was found in 6.3%, 7%, and 9.4% of patients with lung squamous cell carcinoma, lung adenocarcinoma, and esophageal cancer, respectively. Among the geographic areas surveyed, Kagoshima exhibited a significantly higher prevalence of HPV infection in cases of esophageal carcinoma (24.1%). There was no geographical difference in the infection rates of HPV in lung carcinomas. Subtype-specific ISH was also performed, which identified the high-risk HPV types 16/18 in the majority (75.7%) of the patients with lung and esophageal cancer positive for HPV. J. Med. Virol. 83:1383-1390, 2011. (C) 2011 Wiley-Liss, Inc.