An estimate of Lyme borreliosis incidence in Western Europe
An estimate of Lyme borreliosis incidence in Western Europe
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DOI：
10.1093/pubmed/fdw017
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发表时间：
2017-03-01
影响因子：
4.4
通讯作者：
Makiello, Phoebe
中科院分区：
文献类型：
--
作者：
Sykes, Robert A.;Makiello, Phoebe
研究背景莱姆病（LB）是美国和欧洲最常见的由蜱传播的人畜共患病。本综述旨在估计LB在西欧的区域负担。将使用既往出版物的数据计算平均发生率。然后将平均发病率结合起来，以估计区域负担和人口-根据纳入研究的标准化发病率和总风险人群的加权区域疾病负担。方法首先通过标题和摘要评估由初始数据库检索确定的综述和监测报告的合格性，然后由两位独立作者对来源进行更详细的综述关于LB的最新数据。11个发病率数据来源被纳入审查，共代表17个国家。发病率估计值计算报告值和人口data.Results国家inWestern欧洲的发病率有很大的差异。报告的LB发生率最高的是瑞典南部，为464/10万，最低的是意大利，为0.001/10万。纳入数据的未加权平均数提供的发病率为56.3/100 000人/年，相当于整个区域1年内发生232 125例病例。LB的区域负担inWestern Europe的人口加权平均发病率为22.05例/100 000人year.Conclusions LB是一种不断出现的疾病和最常见的人畜共患感染inWestern Europe接近地方病的比例在许多欧洲国家。本研究估计的人群加权发病率为22.04/10万人-年。应继续鼓励进行协调一致和良好的监测和提高疾病意识，以监测LB，因为蜱虫数量和活动正在增加，导致感染风险增加。
Background Lyme borreliosis (LB) is the most common zoonotic disease transmitted by ticks in the USA and Europe. This review aims to estimate the regional burden of LB inWestern Europe. Data from previous publications will be used to calculate the mean incidence. The mean incidence rates will then be combined to estimate the regional burden and a population-weighted regional burden of disease based on the standardized incidence rate from the included studies and the total population at risk.Methods Reviews and surveillance reports identified by the initial database search were assessed for eligibility first by their title and abstract and subsequently by a more detailed review of the source by two independent authors for the most recent data regarding LB. Eleven sources of incidence data were included in the review representing 17 countries in total. Incidence estimates were calculated from reported values and population data.Results Countries inWestern Europe have a large variance in the incidence rates. The highest reported incidences for LB were reported in southern Sweden with 464/100 000 and the lowest in Italy of 0.001/100 000. The unweighted mean for the included data provided an incidence rate of 56.3/100 000 persons per year, equating to similar to 232 125 cases in 1 year throughout the region. The calculated population-weighted average incidence rate for the regional burden of LB inWestern Europe was 22.05 cases per 100 000 person-years.Conclusions LB is a continually emerging disease and the most common zoonotic infection inWestern Europe approaching endemic proportions in many European countries. The population-weighted incidence rate has been estimated by this study to be 22.04/100 000 person-years. Concordant and well-conducted surveillance and disease awareness should continue to be encouraged to monitor LB, as tick numbers and activity are increasing, leading to greater risks of infection.