A clinical method for assessing the ventilatory response to hypoxia.
A clinical method for assessing the ventilatory response to hypoxia.
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DOI：
10.1164/arrd.1974.109.3.345
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
A. Rebuck;E. Campbell
中科院分区：
文献类型：
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作者：
A. Rebuck;E. Campbell
建立了一种适合于临床应用的评估低氧呼吸反应的方法。我们使用重复呼吸法来制造进行性低氧，保持二氧化碳分压恒定，并根据血氧饱和度而不是氧分压来绘制通气图。受试者从一个6升的袋子里呼吸，最初含有7%的二氧化碳，24%的氧气，其余的是氮气。通过可变的二氧化碳吸收旁路将呼气末二氧化碳分压维持在“混合静脉”水平。持续重复呼吸，直到呼气末PO2降至30-40毫米汞柱(饱和度为50%-60%)。用耳氧仪连续测定血氧饱和度。9名正常受试者的换气时间除以血氧饱和度变化的个体间范围为每1%血氧饱和度(SO2)下降0.26至4.12升/分钟，并在所有研究中得到线性曲线图。在重复研究中，受试者之间的反应差异明显小于受试者之间的差异(F=10.15；p<；0.01)。文蒂..。
A method for assessing the ventilatory response to hypoxia suitable for clinical application was developed. We used a rebreathing method to create progressive hypoxia, kept Pco2 constant, and plotted ventilation against oxygen saturation rather than against oxygen tension. Subjects rebreathed from a 6-liter bag initially containing 7 per cent CO2, 24 per cent O2, and the balance N2. End-tidal Pco2 was held at “mixed venous” level by a variable CO2 absorbing bypass. Rebreathing was continued until end-tidal Po2 fell to 30 to 40 mm Hg (saturation 50 to 60 per cent). Oxygen saturation was measured continuously by ear oximetry. The interindividual range in 9 normal subjects for the change in expired ventilation divided by the change in oxygen saturation was 0.26 to 4.12 liters per min per 1 per cent fall in oxygen saturation (So2), and in all studies, linear plots were obtained. In repeated studies, variation in response within subjects was significantly less than between subjects (F = 10.15; p < 0.01). Venti...