Improved Targeting of Cancers with Nanotherapeutics
Improved Targeting of Cancers with Nanotherapeutics
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DOI：
10.1007/978-1-4939-6646-2_2
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Kamaly, Nazila
中科院分区：
文献类型：
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作者：
Foster, Christian;Watson, Andre;Kamaly, Nazila
靶向癌症纳米疗法为在肿瘤和癌细胞内选择性吸收有毒化疗药物提供了大量机会。纳米粒子的独特性质，如其小的尺寸，大的比表面积比，以及在其表面实现多价靶向配体的能力，为基于纳米粒子的药物输送到各种癌症提供了优越的优势。本文着重介绍了肿瘤靶向治疗纳米药物设计中的各种关键概念，并讨论了影响纳米粒子靶向的物理化学参数，以及肿瘤靶向纳米药物的最新发展。
Targeted cancer nanotherapeutics offers numerous opportunities for the selective uptake of toxic chemotherapies within tumors and cancer cells. The unique properties of nanoparticles, such as their small size, large surface-to-volume ratios, and the ability to achieve multivalency of targeting ligands on their surface, provide superior advantages for nanoparticle-based drug delivery to a variety of cancers. This review highlights various key concepts in the design of targeted nanotherapeutics for cancer therapy, and discusses physicochemical parameters affecting nanoparticle targeting, along with recent developments for cancer-targeted nanomedicines.