Movement of the human upper airway during inspiration with and without inspiratory resistive loading
Movement of the human upper airway during inspiration with and without inspiratory resistive loading
复制标题
DOI：
10.1152/japplphysiol.00413.2010
复制
发表时间：
2011-01-01
影响因子：
3.3
通讯作者：
Bilston, L. E.
中科院分区：
文献类型：
--
作者：
Cheng, S.;Butler, J. E.;Bilston, L. E.
Cheng S，Butler JE，Gandevia SC，Bilston LE.在有和没有吸气阻力负荷的吸气过程中人体上气道的运动。J Appl Physiol 110：69-75，2011.首次发表于2010年10月21日; doi：10.1152/japplphysiol.00413.2010.-人体上呼吸道肌肉，特别是颏舌肌的肌电图（EMG）活动已被广泛测量，但EMG活动与呼吸道肌肉的物理运动之间的关系仍不清楚。我们的目的是测量在正常和负荷吸气过程中气道周围软组织的运动，假设这种运动会受到吸气过程中呼吸阻力增加的影响。7名健康受试者在3-T扫描仪上进行标记MR成像。使用带标记的8.6 mm间距网格，并在吸气气流前200 ms开始采集磁化图像的互补空间调制。测量标记线交叉点的变形。正常吸气和负荷吸气时颏舌肌向前移动，负荷吸气时颏舌肌移动较少。上气道前缘组织运动不均匀，向前运动较大。在软腭水平，气道的横向尺寸在负荷吸气期间显著减小（在无负荷和负荷吸气期间分别为-0.15 +/-0.09和-0.48 +/-0.09 mm，P < 0.05）。当增加吸气气流阻力时，颏舌肌运动和软腭水平气道的横向尺寸减小。我们的研究结果表明，颏舌肌运动开始早，在气流和吸气负荷减少颏舌肌的前运动，并增加软腭水平的侧气道壁的塌陷之前，气道扩张。
Cheng S, Butler JE, Gandevia SC, Bilston LE. Movement of the human upper airway during inspiration with and without inspiratory resistive loading. J Appl Physiol 110: 69-75, 2011. First published October 21, 2010; doi:10.1152/japplphysiol.00413.2010.-The electromyographic (EMG) activity of human upper airway muscles, particularly the genioglossus, has been widely measured, but the relationship between EMG activity and physical movement of the airway muscles remains unclear. We aimed to measure the motion of the soft tissues surrounding the airway during normal and loaded inspiration on the basis of the hypothesis that this motion would be affected by the addition of resistance to breathing during inspiration. Tagged MR imaging of seven healthy subjects was performed in a 3-T scanner. Tagged 8.6-mm-spaced grids were used, and complementary spatial modulation of magnetization images were acquired beginning similar to 200 ms before inspiratory airflow. Deformation of tag line intersections was measured. The genioglossus moved anteriorly during normal and loaded inspiration, with less movement during loaded inspiration. The motion of tissues at the anterior border of the upper airway was nonuniform, with larger motions inferiorly. At the level of the soft palate, the lateral dimension of the airway decreased significantly during loaded inspiration (-0.15 +/- 0.09 and -0.48 +/- 0.09 mm during unloaded and loaded inspiration, respectively, P < 0.05). When resistance to inspiratory flow was added, genioglossus motion and lateral dimensions of the airway at the level of the soft palate decreased. Our results suggest that genioglossus motion begins early to dilate the airway prior to airflow and that inspiratory loading reduces the anterior motion of the genioglossus and increases the collapse of the lateral airway walls at the level of the soft palate.