Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS
Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS
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DOI：
10.1097/qad.0b013e328358daea
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发表时间：
2012-10-23
期刊：
影响因子：
3.8
通讯作者：
Makinson, Alain
中科院分区：
文献类型：
--
作者：
Brunel, Anne-Sophie;Reynes, Jacques;Makinson, Alain
尽管皮质类固醇治疗，复发或难治性免疫重建炎症综合征（IRISs）的管理尚未明确。我们描述了三名感染艾滋病毒的患者，他们患有依赖皮质类固醇和危及生命的矛盾免疫重建炎症综合征，沙利度胺治疗导致快速临床缓解，并允许完全停用皮质类固醇而没有临床复发。
Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined. We describe three HIV-infected patients with corticosteroid-dependent and life-threatening paradoxical immune reconstitution inflammatory syndrome for whom thalidomide treatment induced rapid clinical remission and permitted complete corticosteroid withdrawal without clinical relapse.