Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin.
Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin.
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DOI：
10.1016/j.mce.2012.01.025
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发表时间：
2012-08-15
影响因子：
4.1
通讯作者：
Vale, Wylie W.
中科院分区：
文献类型：
--
作者：
Bilezikjian, Louise M.;Justice, Nicholas J.;Blackler, Alissa N.;Wiater, Ezra;Vale, Wylie W.
激活素是多功能蛋白质，是 TGF-β 超家族的成员。激活素在大多数组织中局部表达，与这个多效性因子大家族其他成员的作用类似，激活素在分化干细胞和胚胎干细胞的多种生物过程的调节中发挥着重要作用。它们在维持成人组织稳态方面发挥着重要作用，并且已知有助于胚胎的发育程序。激活素进一步涉及肿瘤细胞的生长和转移。通过不同的作用模式，抑制素和卵泡抑素作为激活素和其他几个 TGF-β 家族成员（包括 BMP/GDF 的子集）的拮抗剂发挥作用，并调节细胞反应和这些配体下游的信号级联。在垂体中，已知激活素途径可调节促性腺激素功能的关键方面，并对其他垂体细胞类型产生影响。与其他组织一样，激活素由垂体细胞局部产生，并通过对促性腺激素发挥细胞类型特异性作用来局部发挥作用。激活素对促性腺激素的这些局部作用受到局部分泌的卵泡抑素的自分泌/旁分泌作用和性腺抑制素的反馈作用的调节。关于激活素、抑制素和卵泡抑素作用机制的知识提供了有关它们对垂体功能的重要性以及它们对垂体腺瘤病理生理学的贡献的信息。本综述的目的是强调最近的发现，并总结支持激活素、抑制素和卵泡抑素在垂体中重要功能的证据。
Activins are multifunctional proteins and members of the TGF-β superfamily. Activins are expressed locally in most tissues and, analogous to the actions of other members of this large family of pleiotropic factors, play prominent roles in the regulation of diverse biological processes in both differentiated and embryonic stem cells. They have an essential role in maintaining tissue homeostasis in the adult and are known to contribute to the developmental programs in the embryo. Activins are further implicated in the growth and metastasis of tumor cells. Through distinct modes of action, inhibins and follistatins function as antagonists of activin and several other TGF-β family members, including a subset of BMPs/GDFs, and modulate cellular responses and the signaling cascades downstream of these ligands. In the pituitary, the activin pathway is known to regulate key aspects of gonadotrope functions and also exert effects on other pituitary cell types. As in other tissues, activin is produced locally by pituitary cells and acts locally by exerting cell-type specific actions on gonadotropes. These local actions of activin on gonadotropes are modulated by the autocrine/paracrine actions of locally secreted follistatin and by the feedback actions of gonadal inhibin. Knowledge about the mechanism of activin, inhibin and follistatin actions is providing information about their importance for pituitary function as well as their contribution to the pathophysiology of pituitary adenomas. The aim of this review is to highlight recent findings and summarize the evidence that supports the important functions of activin, inhibin and follistatin in the pituitary.
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影响因子：
4.8
作者：
BILEZIKJIAN, LM;VAUGHAN, JM;VALE, WW
通讯作者：
VALE, WW
影响因子：
4.8
作者：
Blount, Amy L.;Schmidt, Karsten;Bilezikjian, Louise M.
通讯作者：
Bilezikjian, Louise M.
DOI：
10.1073/pnas.0602558103
发表时间：
2006-05-16
影响因子：
11.1
作者：
Allendorph, George P.;Vale, Wylie W.;Choe, Senyon
通讯作者：
Choe, Senyon
影响因子：
4.8
作者：
Chapman, SC;Woodruff, TK
通讯作者：
Woodruff, TK
影响因子：
4.8
作者：
Bilezikjian, LM;Corrigan, AZ;Vale, WW
通讯作者：
Vale, WW