Mechanisms Underlying the Antifibrotic Potential of Estradiol for Vocal Fold Fibrosis
Mechanisms Underlying the Antifibrotic Potential of Estradiol for Vocal Fold Fibrosis
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DOI：
10.1002/lary.29355
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发表时间：
2020-12
期刊：
影响因子：
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通讯作者：
S. Ozawa;S. Mukudai;Y. Sugiyama;R. Branski;S. Hirano
中科院分区：
文献类型：
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作者：
S. Ozawa;S. Mukudai;Y. Sugiyama;R. Branski;S. Hirano
声带纤维化仍然是一个重大的临床挑战。雌激素是导致女性第二性征的主要类固醇激素，已被证明可以改变伤口愈合和限制纤维化，但对声带纤维化的影响尚不清楚。本研究旨在阐明雌激素受体在大鼠声带成纤维细胞中的表达及雌激素对转化生长因子-β-1信号转导的影响。
Vocal fold fibrosis remains a significant clinical challenge. Estrogens, steroid hormones predominantly responsible for secondary sexual characteristics in women, have been shown to alter wound healing and limit fibrosis, but the effects on vocal fold fibrosis are unknown. We sought to elucidate the expression of estrogen receptors and the effects of estrogens on TGF‐β1 signaling in rat vocal fold fibroblasts (VFFs).