Curcumin loaded mesoporous silica: an effective drug delivery system for cancer treatment
Curcumin loaded mesoporous silica: an effective drug delivery system for cancer treatment
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DOI：
10.1039/c5bm00552c
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发表时间：
2016-01-01
影响因子：
6.6
通讯作者：
Gomez-Ruiz, Santiago
中科院分区：
文献类型：
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作者：
Kotcherlakota, Rajesh;Barui, Ayan Kumar;Gomez-Ruiz, Santiago
在本研究中，我们报告了使用介孔二氧化硅材料将抗癌药物姜黄素递送至癌细胞。首先通过对KIT-6、MSU-2和MCM-41进行胺功能化，然后负载姜黄素，设计和开发了一系列基于介孔二氧化硅材料的药物递送系统（S2、S4和S6）。姜黄素负载材料通过多种物理化学技术进行表征，并在癌细胞上进行彻底筛选，以评估其体外药物递送功效。与原始姜黄素相比，所有负载姜黄素的二氧化硅材料都表现出更高的细胞摄取和对癌细胞活力的抑制。与游离姜黄素相比，姜黄素通过介孔二氧化硅材料在癌细胞中有效内化，引发细胞内活性氧的产生，并下调聚 ADP 核糖聚合酶 (PARP) 酶水平，从而激活细胞凋亡。这项研究表明，通过负载到介孔二氧化硅材料上可以增强姜黄素的抗癌活性。因此，我们坚信基于介孔二氧化硅的姜黄素负载药物递送系统可能具有未来治疗癌症的潜在应用。
In the present study, we report the delivery of anti-cancer drug curcumin to cancer cells using mesoporous silica materials. A series of mesoporous silica material based drug delivery systems (S2, S4 and S6) were first designed and developed through the amine functionalization of KIT-6, MSU-2 and MCM-41 followed by the loading of curcumin. The curcumin loaded materials were characterized with several physico-chemical techniques and thoroughly screened on cancer cells to evaluate their in vitro drug delivery efficacy. All the curcumin loaded silica materials exhibited higher cellular uptake and inhibition of cancer cell viability compared to pristine curcumin. The effective internalization of curcumin in cancer cells through the mesoporous silica materials initiated the generation of intracellular reactive oxygen species and the down regulation of poly ADP ribose polymerase (PARP) enzyme levels compared to free curcumin leading to the activation of apoptosis. This study shows that the anti-cancer activity of curcumin can be potentiated by loading onto mesoporous silica materials. Therefore, we strongly believe that mesoporous silica based curcumin loaded drug delivery systems may have future potential applications for the treatment of cancers.