A Three-Dimensional Quantitative Method to Measure Meniscus Shape, Position, and Signal Intensity Using MR Images: A Pilot Study and Preliminary Results in Knee Osteoarthritis
A Three-Dimensional Quantitative Method to Measure Meniscus Shape, Position, and Signal Intensity Using MR Images: A Pilot Study and Preliminary Results in Knee Osteoarthritis
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DOI：
10.1002/mrm.22380
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发表时间：
2010-05-01
影响因子：
3.3
通讯作者：
Eckstein, Felix
中科院分区：
文献类型：
--
作者：
Wirth, Wolfgang;Frobell, Richard B.;Eckstein, Felix
该初步研究提出了一种半月板形状、位置和信号强度的三维和定量分析技术，并比较了20例和11例膝关节放射学骨关节炎患者的结果。3-T MR采用质子密度加权、脂肪抑制、冠状位、快速自旋回波序列，层厚2mm。对胫骨、股骨和内侧半月板的外表面以及胫骨关节面进行分割。计算三维参数以描述整个半月板和三个亚区（体、前角和后角）的形状、位置和信号强度。主要结果包括更大的尺寸（即，体积、表面积和厚度），增加的内侧挤压（即，与非骨关节炎膝关节相比，骨关节炎膝关节内侧半月板的突出距离更大，胫骨表面未覆盖的关节面面积更大），信号强度更高，尤其是半月板体。这些结果需要在更大的队列中得到证实，最好是在负重条件下。Magn Reson Med 63：1162 - 1171，2010。(C)2010 Wiley-Liss，Inc.
This pilot study presents a technique for three-dimensional and quantitative analysis of meniscus shape, position, and signal intensity and compares results in knees with (n = 20) and without (n = 11) radiographic osteoarthritis. 3-T MR images with 2mm section thickness were acquired using a proton density weighted, fat-suppressed, coronal, fast spin-echo sequence. Segmentation of the tibial, femoral, and external surface of the medial meniscus and the tibial joint surface was performed. Three-dimensional parameters were computed to describe the shape, position, and signal intensity of the entire meniscus and three subregions (body, anterior, and posterior horn). Key results included a greater size (i.e., volume, surface areas, and thickness), increased medial extrusion (i.e., greater extrusion distance, greater meniscal area uncovered by tibial surface), and elevated signal intensity of the medial meniscus in osteoarthritis than in nonosteoarthritis knees, particularly in the meniscus body. These results need to be confirmed in larger cohorts, preferably under weight-bearing conditions. Magn Reson Med 63:1162-1171, 2010. (C) 2010 Wiley-Liss, Inc.