PREVENTION OF T-CELL ANERGY BY SIGNALING THROUGH THE GAMMA(C) CHAIN OF THE IL-2 RECEPTOR
PREVENTION OF T-CELL ANERGY BY SIGNALING THROUGH THE GAMMA(C) CHAIN OF THE IL-2 RECEPTOR
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DOI：
10.1126/science.7973657
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发表时间：
1994-11-11
期刊：
影响因子：
56.9
通讯作者：
NADLER, LM
中科院分区：
文献类型：
--
作者：
BOUSSIOTIS, VA;BARBER, DL;NADLER, LM
当通过它们的抗原受体刺激而没有必要的共刺激时，T细胞进入抗原特异性无反应性的状态，称为无反应性。在这项研究中，发现在抗原存在下通过白细胞介素-2（IL-2）、IL-4和IL-7受体的共同γ链的信号传导足以防止无反应性的诱导。在与IL-2、IL-4或IL-7培养后，Jak 3激酶被酪氨酸磷酸化，这与无反应性的预防相关。因此，通过共同γ链的信号可以调节T细胞的决定，以克隆扩增或进入无反应性状态。
When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness, termed anergy. In this study, signaling through the common gamma chain of the interleukin-2 (IL-2), IL-4, and IL-7 receptors in the presence of antigen was found to be sufficient to prevent the induction of anergy. After culture with IL-2, IL-4, or IL-7, Jak3 kinase was tyrosine-phosphorylated, which correlated with the prevention of anergy. Therefore, a signal through the common gamma chain may regulate the decision of T cells to either clonally expand or enter a state of anergy.