Association of Peripheral Arterial and Cardiovascular Diseases in Familial Hypercholesterolemia
Association of Peripheral Arterial and Cardiovascular Diseases in Familial Hypercholesterolemia
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DOI：
10.5935/abc.20140097
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发表时间：
2014-08-01
影响因子：
2.6
通讯作者：
Santos, Raul D.
中科院分区：
文献类型：
--
作者：
Pereira, Carolina;Miname, Marcio;Santos, Raul D.
背景：家族性高胆固醇血症(FH)是一种常染色体显性遗传病，其特征是血清总胆固醇和低密度脂蛋白水平升高。众所周知，FH与动脉粥样硬化过程密切相关，可以确定不同动脉床上早期梗阻病变的发展。在这种背景下，FH也被认为是外周动脉疾病(PAD)的危险因素。目的：这项观察性横断面研究评估了PAD与其他心血管疾病(CVD)表现的相关性，如冠状动脉和脑血管疾病，在杂合子FH患者中。方法：通过踝臂指数(ABI)值建立PAD的诊断
Background: Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease characterized by an elevation in the serum levels of total cholesterol and of low-density lipoproteins (LDL-c). Known to be closely related to the atherosclerotic process, FH can determine the development of early obstructive lesions in different arterial beds. In this context, FH has also been proposed to be a risk factor for peripheral arterial disease (PAD).Objective: This observational cross-sectional study assessed the association of PAD with other manifestations of cardiovascular disease (CVD), such as coronary artery and cerebrovascular disease, in patients with heterozygous FH.Methods: The diagnosis of PAD was established by ankle-brachial index (ABI) values