Circulating beta amyloid protein is elevated in patients with acute ischemic stroke
Circulating beta amyloid protein is elevated in patients with acute ischemic stroke
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DOI：
10.1007/s00702-004-0274-0
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发表时间：
2005-10-01
影响因子：
3.3
通讯作者：
Huh, K
中科院分区：
文献类型：
--
作者：
Lee, PH;Bang, OY;Huh, K
最近的临床和实验研究表明，缺血性卒中可能在阿尔茨海默病（AD）的发病机制中起重要作用。-淀粉样蛋白（Ab）是阿尔茨海默病老年斑的主要成分，已知来自缺血脑或活化的血小板。我们前瞻性地招募了62例急性缺血性卒中患者和27例年龄匹配的对照组。采用Sandwich-ELISA法测定血清Ab和p -选择素水平。我们根据缺血性脑卒中的临床证候、发病机制和梗死面积将其分为亚组，并比较各亚组间的Ab水平。与对照组相比，缺血性卒中患者A β 1-40水平显著升高（140.2 +/- 54.0 vs 88.44 +/- 34.96 pg= ml, p< 0.001）。心栓子性和大动脉粥样硬化性梗死的A β 1-40水平高于小血管疾病（p= 0.001）。梗死面积和初始NIHSS评分与血清A β 1-40水平呈显著正相关（r = 0.539, p< 0.001和r = 0.425, p = 0.001）。p -选择素水平与血清A β 1-40无显著相关。我们的数据表明，缺血性卒中患者循环A β 1-40升高。
Recent clinical and experimental studies suggest that ischemic strokes may play an important role in the pathogenesis of Alzheimer's disease ( AD). Beta amyloid ( Ab), a major component of senile plaque in AD, is known to be derived from ischemic brain or activated platelets. We prospectively enrolled 62 patients with acute ischemic stroke and 27 age-matched controls. The serum Ab and P-selectin levels were determined using the Sandwich-ELISA. We divided ischemic strokes into subgroups according to the clinical syndrome, pathogenesis, and infarct size, and compared the Ab level between each subgroup. The A beta 1-40 level was markedly elevated in ischemic stroke patients, as compared to controls (140.2 +/- 54.0 vs 88.44 +/- 34.96 pg= ml, p< 0.001). Cardioembolic and larger artery atherosclerotic infarcts had higher A beta 1-40 level than small vessel disease (p= 0.001). Both infarct size and the initial NIHSS score had significantly positive correlations with the serum level of A beta 1-40 ( r = 0.539, p< 0.001 and r = 0.425, p = 0.001, respectively). However, the P-selectin level was not significantly correlated with serum A beta 1-40. Our data suggest that elevated circulating A beta 1-40 in ischemic stroke.