Resting-state oscillatory brain dynamics in Alzheimer disease
Resting-state oscillatory brain dynamics in Alzheimer disease
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DOI：
10.1097/wnp.0b013e31817da184
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发表时间：
2008-08-01
影响因子：
2.4
通讯作者：
Scheltens, Philip
中科院分区：
文献类型：
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作者：
de Haan, Willem;Stam, Cornelis J.;Scheltens, Philip
阿尔茨海默病（AD）的振荡脑活动改变可能反映了潜在的神经病理改变，其特征可能导致新的诊断可能性。本研究采用定量脑磁图技术来检测阿尔茨海默病患者的功率谱变化及其诊断强度。闭眼静息状态下记录全头151通道脑磁图。将脑磁图通道分为10个皮质区，分析常用频段的全局和区域相对功率。18例AD患者[平均年龄72.1岁+/- 5.6 (SD)；7女人;平均迷你精神状态检查得分19.2，范围：13-25]和18名健康对照[平均年龄69.1 +/- 6.8 (SD)， 11名女性；平均迷你精神状态检查得分29分（范围27-30分），对照组主要为患者配偶。相对功率分析显示，在大多数频带，特别是在颞顶叶区域，具有显著差异，与迷你精神状态考试分数有一定关系。β波段诊断准确率最高，尤其是在右侧枕区（敏感性94%，特异性78%）。脑磁图记录的定量相对功率分析能够显示AD患者振荡脑动力学的广泛异常。通过分析不同的皮层区域，本研究提供了AD患者异常大脑活动的更详细的地形视图。
Altered oscillatory brain activity in Alzheimer disease (AD) may reflect underlying neuropathological changes, and its characterization might lead to new diagnostic possibilities. The present study using quantitative magnetoencephalography was set up to examine power spectrum changes in AD patients, and their diagnostic strength. Whole-head 151-channel magnetoencephalography was recorded during an eyes-closed resting state. Magnetoencephalography channels were grouped in 10 cortical regions, and both global and regional relative power was analyzed for the commonly used frequency bands. Eighteen AD patients [mean age 72.1 years +/- 5.6 (SD); 7 women; mean Mini Mental State Examination score 19.2, range: 13-25] and 18 healthy controls [mean age 69.1 +/- 6.8 (SD), 11 women; mean Mini Mental State Examination score 29, range: 27-30] were recruited, controls being mainly spouses of patients. Relative power analysis showed significant differences in most frequency bands, particularly in the temporoparietal regions, with some relation to Mini Mental State Examination scores. Greatest diagnostic accuracy was found in the beta band, especially in the right occipital area (sensitivity 94%, specificity 78%). Quantitative relative power analysis of magnetoencephalography recordings is able to show widespread abnormalities in oscillatory brain dynamics in AD patients. By analyzing distinct cortical regions, this Study provides a more detailed topographical view of abnormal brain activity in AD.