Diagnostic value of alpha-fetoprotein, Lens culinaris agglutinin-reactive alpha-fetoprotein, and des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular carcinoma.
Diagnostic value of alpha-fetoprotein, Lens culinaris agglutinin-reactive alpha-fetoprotein, and des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular carcinoma.
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甲胎蛋白、菜豆凝集素反应性甲胎蛋白、脱γ-羧基凝血酶原对乙型肝炎病毒相关性肝细胞癌的诊断价值
DOI：
10.1177/0300060519889270
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发表时间：
2020-03
期刊：
影响因子：
--
通讯作者：
Wu H
中科院分区：
文献类型：
--
作者：
Song T;Wang L;Su B;Zeng W;Jiang T;Zhang T;Sun G;Wu H
目的 本研究旨在探讨甲胎蛋白（AFP）、菜豆凝集素反应性甲胎蛋白（AFP-L3）和脱γ-羧基凝血酶原（DCP）的不同组合在乙型肝炎病毒（HBV）相关性肝硬化（LC）患者肝细胞癌（HCC）早期诊断中的应用。方法 167 例受试者纳入本研究，其中 HCC 100 例，LC 67 例。采用化学发光酶联免疫分析法检测血清AFP、AFP-L3和DCP水平，并采用受试者工作特征（ROC）法进行分析。结果 AFP 和 DCP 区分早期 HCC 和 HBV 相关 LC 的敏感性和特异性分别为 51.5% 和 92.5%、60.0% 和 84.7%。 ROC曲线的比较分析显示AFP和DCP的曲线下面积(AUC)没有显着差异。此外，AFP 和 DCP 组合显示出最大的 AUC 值，诊断敏感性和特异性分别为 67% 和 83.1%。结论 这些结果表明，AFP 是区分 HBV 相关 LC 和 HBV 诱导的早期 HCC 的最佳单一生物标志物。然而，AFP和DCP的联合可以增强AFP对于区分这些疾病的诊断价值。
Objective This study aimed to explore the use of different combinations of alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-gamma-carboxyprothrombin (DCP) for the early diagnosis of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-associated liver cirrhosis (LC). Methods There were 167 subjects, including 100 with HCC and 67 with LC, who were enrolled into this study. Serum AFP, AFP-L3, and DCP levels were detected by chemiluminescent enzyme immunoassay and analyzed using the receiver operating characteristics (ROC) method. Results The sensitivity and specificity of AFP and DCP for differentiating between early HCC and HBV-associated LC were 51.5% and 92.5%, and 60.0% and 84.7%, respectively. Comparative analysis of ROC curves showed no significant difference in the area under the curve (AUC) for AFP and DCP. Moreover, the combination of AFP and DCP showed the largest AUC value with a diagnostic sensitivity and specificity of 67% and 83.1%, respectively. Conclusion These results suggest that AFP is the best single biomarker for distinguishing between HBV-associated LC and early HCC induced by HBV. However, the combination of AFP and DCP can enhance the diagnostic value of AFP for differentiating between these diseases.
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影响因子：
12.6
作者：
Berhane, Sarah;Toyoda, Hidenori;Johnson, Philip
通讯作者：
Johnson, Philip
影响因子：
4.1
作者：
Kim, Bo Hyun;Lim, Young-Suk;Hwang, Jae Seok
通讯作者：
Hwang, Jae Seok
影响因子：
3.7
作者：
Ji J;Wang H;Li Y;Zheng L;Yin Y;Zou Z;Zhou F;Zhou W;Shen F;Gao C
通讯作者：
Gao C
影响因子：
1.3
作者：
Best, J.;Bilgi, H.;Dechene, A.
通讯作者：
Dechene, A.
DOI：
10.6004/jnccn.2009.0027
发表时间：
2009-04
期刊：
Journal of the National Comprehensive Cancer Network : JNCCN
影响因子：
--
作者：
Benson AB 3rd;Abrams TA;Ben-Josef E;Bloomston PM;Botha JF;Clary BM;Covey A;Curley SA;D'Angelica MI;Davila R;Ensminger WD;Gibbs JF;Laheru D;Malafa MP;Marrero J;Meranze SG;Mulvihill SJ;Park JO;Posey JA;Sachdev J;Salem R;Sigurdson ER;Sofocleous C;Vauthey JN;Venook AP;Goff LW;Yen Y;Zhu AX
通讯作者：
Zhu AX