Modification of calcium phosphate cement with poly (γ-glutamic acid) and its strontium salt for kyphoplasty application
Modification of calcium phosphate cement with poly (γ-glutamic acid) and its strontium salt for kyphoplasty application
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聚(γ-谷氨酸)及其锶盐改性磷酸钙骨水泥用于椎体后凸成形术
DOI：
10.1016/j.msec.2017.05.070
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发表时间：
2017-11-01
影响因子：
7.9
通讯作者：
Yang, Lei
中科院分区：
文献类型：
--
作者：
Gao, Chunxia;Liu, Huiling;Yang, Lei
为了满足微创手术治疗腰椎压缩性骨折的要求，人们提出了各种策略来增强磷酸钙骨水泥（CPC）的性能。在这里，开发了一种新的策略，将聚（γ-谷氨酸）（γ-PGA）和它的锶盐的α磷酸三钙（α-TCP）为基础的CPC的配方。系统研究了γ-PGA对骨水泥注射性能、内聚性、凝固时间、力学压缩强度和细胞相容性的影响。结果表明，-γ-PGA的引入显著改善了CPC的可注射性、内聚性和凝结时间。而且，在凝固7天后，抗压强度从纯CPC的14.6 +/- 1.4 MPa增加到具有8.9重量% γ-PGA的CPC的35.3 +/- 1.7 MPa，并且进一步增加到具有8.9重量% γ-PGA的CPC的61.2 +/- 5.4 MPa。体外成骨细胞增殖实验表明，γ-PGA及其锶盐修饰的CPC组细胞相容性优于单纯CPC组。所有结果表明，在固相中添加8.9wt% γ-PGA并使用锶盐作为反应液相的骨水泥获得了最佳性能，使其成为椎体后凸成形术中应用的有希望的候选物。(C)2017爱思唯尔B. V.保留所有权利。
To meet the requirements of minimally invasive surgical treatments for osteoporotic vertebral compression fracture, various strategies have been proposed to enhance the properties of calcium phosphate cement (CPC). Here, a new strategy was developed by incorporating poly (gamma-glutamic acid) (gamma-PGA) and its strontium salt into the formulation of alpha tricalcium phosphate (alpha-TCP)-based CPC. Effects of gamma-PGA on the injectability, cohesion, setting times, mechanical compressive strengths and cytocompatibility were systematically studied. Results showed that the injectability, cohesion and setting times were considerably improved by introducing-gamma-PGA into the CPC. Moreover, after setting for 7 days, the compressive strengths increased from 14.6 +/- 1.4 MPa for pure CPC to 35.3 +/- 1.7 MPa for CPC with 8.9 wt% gamma-PGA and further to 61.2 +/- 5.4 MPa for CPC with 8.9 wt% gamma-PGA combined with its strontium salt In vitro osteoblast proliferation tests showed that the group of CPC modified by gamma-PGA and its strontium salt had better cytocompatibility than the pure CPC group. All results suggest that optimal properties were obtained for the cement with 8.9 wt% gamma-PGA added to its solid phases and using strontium salt as the reactive liquid phase, malting it as a promising candidate for application in kyphoplasty. (C) 2017 Elsevier B.V. All rights reserved.