The structural basis of intraflagellar transport at a glance
The structural basis of intraflagellar transport at a glance
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DOI：
10.1242/jcs.247163
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发表时间：
2021-06-01
影响因子：
4
通讯作者：
Pigino, Gaia
中科院分区：
文献类型：
--
作者：
Jordan, Mareike A.;Pigino, Gaia
鞭毛内转运（IFT）系统是细胞用于组装和维持纤毛的显著分子机器，纤毛是从真核细胞延伸的长细胞器，其产生运动、传感和信号传导。IFT通过在纤毛基部和顶端之间穿梭结构组分和信号受体在纤毛的构建中起关键作用。为了提供有效的运输，IFT-A和IFT-B衔接蛋白复合物组装成高度重复的聚合物，称为IFT序列，其由马达驱动蛋白-2和IFT-动力蛋白提供动力，以沿着微管双向沿着移动。这个动态系统必须被精确地调节，以在纤毛尖端和基部之间穿梭不同的货物蛋白。在这篇Cell Science at a Glance文章和随附的海报中，我们讨论了目前对IFT列车的结构和机制的理解，以及它们如何作为大分子机器组装纤毛结构。
The intraflagellar transport (IFT) system is a remarkable molecular machine used by cells to assemble and maintain the cilium, a long organelle extending from eukaryotic cells that gives rise to motility, sensing and signaling. IFT plays a critical role in building the cilium by shuttling structural components and signaling receptors between the ciliary base and tip. To provide effective transport, IFT-A and IFT-B adaptor protein complexes assemble into highly repetitive polymers, called IFT trains, that are powered by the motors kinesin-2 and IFT-dynein to move bidirectionally along the microtubules. This dynamic system must be precisely regulated to shuttle different cargo proteins between the ciliary tip and base. In this Cell Science at a Glance article and the accompanying poster, we discuss the current structural and mechanistic understanding of IFT trains and how they function as macromolecular machines to assemble the structure of the cilium.