A concise route to benzofused macrolactones via ynolides: cycloproparadicicol.
A concise route to benzofused macrolactones via ynolides: cycloproparadicicol.
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DOI：
10.1002/chin.200348212
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发表时间：
2003-07
影响因子：
15
通讯作者：
Zhi-qiang Yang;S. Danishefsky
中科院分区：
文献类型：
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作者：
Zhi-qiang Yang;S. Danishefsky
已经开发了一种新的用于纳摩尔Hsp 90抑制剂环丙甲卡西酚的简易合成方法（2）。我们的方法依赖于钴络合促进的RCM，结合串联Diels-桤木/retro-Diels-桤木反应来组装间苯二酚大环内酯。
A new facile synthesis has been developed for nanomolar Hsp90 inhibitor, cycloproparadicicol (2). Our approach relied on cobalt-complexation promoted RCM, in combination with tandem Diels-Alder/retro-Diels-Alder reactions to assemble the resorcycinylic macrolactone.