Childhood leukemia and parents' occupational and home exposures.
Childhood leukemia and parents' occupational and home exposures.
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DOI：
10.1093/jnci/79.1.39
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发表时间：
1987-07
期刊：
影响因子：
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通讯作者：
R. Lowengart;J. Peters;C. Cicioni;J. Buckley;L. Bernstein;S. Preston‐Martin;E. Rappaport
中科院分区：
文献类型：
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作者：
R. Lowengart;J. Peters;C. Cicioni;J. Buckley;L. Bernstein;S. Preston‐Martin;E. Rappaport
对洛杉矶县10岁及以下儿童进行了一项病例对照研究，以调查白血病的病因。对急性白血病病例的母亲和父亲及其单独匹配的对照组进行了访谈，了解特定的职业和家庭暴露以及与白血病相关的其他潜在危险因素。对123对配对信息的分析显示，父亲在孩子出生后职业性暴露于氯化溶剂的儿童患白血病的风险增加[比值比（OR）= 3.5，P = 0.01]，喷漆（OR = 2.0，P = .02），染料或色素（OR = 4.5，P = .03），甲乙酮（CAS：78-93-3; OR = 3.0，P = .05），切削油（OR = 1.7，P = 0.05）或其父亲在母亲怀孕期间接触喷漆（OR = 2.2，P = 0.03）。对于所有这些，与频繁使用相关的风险大于不频繁使用。如果父亲在制造运输设备（主要是飞机）（OR = 2.5，P = 0.03）或机械（OR = 3.0，P = 0.02）的行业工作，则儿童患白血病的风险增加。父母在家中（OR = 3.8，P = 0.004）或花园（OR = 6.5，P = 0.007）或家中烧香（OR = 2.7，P = 0.007）的儿童的风险增加。频繁使用的风险更大。白血病的风险与母亲在个人服务行业的就业有关（OR = 2.7，P = 0.04），但与特定的职业暴露无关。在对其他重要调查结果进行调整后，与父亲接触氯化溶剂、在运输设备制造业就业以及父母接触家用或花园杀虫剂和熏香有关的风险仍然具有统计学意义。
A case-control study of children of ages 10 years and under in Los Angeles County was conducted to investigate the causes of leukemia. The mothers and fathers of acute leukemia cases and their individually matched controls were interviewed regarding specific occupational and home exposures as well as other potential risk factors associated with leukemia. Analysis of the information from the 123 matched pairs showed an increased risk of leukemia for children whose fathers had occupational exposure after the birth of the child to chlorinated solvents [odds ratio (OR) = 3.5, P = .01], spray paint (OR = 2.0, P = .02), dyes or pigments (OR = 4.5, P = .03), methyl ethyl ketone (CAS: 78-93-3; OR = 3.0, P = .05), and cutting oil (OR = 1.7, P = .05) or whose fathers were exposed during the mother's pregnancy with the child to spray paint (OR = 2.2, P = .03). For all of these, the risk associated with frequent use was greater than for infrequent use. There was an increased risk of leukemia for the child if the father worked in industries manufacturing transportation equipment (mostly aircraft) (OR = 2.5, P = .03) or machinery (OR = 3.0, P = .02). An increased risk was found for children whose parents used pesticides in the home (OR = 3.8, P = .004) or garden (OR = 6.5, P = .007) or who burned incense in the home (OR = 2.7, P = .007). The risk was greater for frequent use. Risk of leukemia was related to mothers' employment in personal service industries (OR = 2.7, P = .04) but not to specified occupational exposures. Risk related to fathers' exposure to chlorinated solvents, employment in the transportation equipment-manufacturing industry, and parents' exposure to household or garden pesticides and incense remains statistically significant after adjusting for the other significant findings.