LEAD AND CADMIUM IN HUMAN PLACENTAS AND MATERNAL AND NEONATAL BLOOD (IN A HEAVILY POLLUTED AREA) MEASURED BY GRAPHITE-FURNACE ATOMIC-ABSORPTION SPECTROMETRY
LEAD AND CADMIUM IN HUMAN PLACENTAS AND MATERNAL AND NEONATAL BLOOD (IN A HEAVILY POLLUTED AREA) MEASURED BY GRAPHITE-FURNACE ATOMIC-ABSORPTION SPECTROMETRY
复制标题
DOI：
10.1136/oem.52.4.229
复制
发表时间：
1995-04-01
影响因子：
4.9
通讯作者：
BARANOWSKA, I
中科院分区：
文献类型：
--
作者：
BARANOWSKA, I
目的：测定人胎盘、母血和新生儿(脐)血中铅、镉的含量。探讨强污染环境对组织中金属含量及胎盘对镉、铅的通透性的影响。分析前对各种矿化方法进行了试验。方法-石墨炉原子吸收光谱法测定铅和镉。结果分析样品中镉、铅的平均含量分别为：静脉血Fb=72.50 ng/ml，Cd=4.90 ng/ml，胎盘Pb0.50mU/g，Cd=0.11mUg/g，胎盘Pd=0.50mU/g，Cd=0.11mU/g。脐血铅含量为38.31 ng/ml，镉含量为1.13 ng/ml。结论胎盘和母血中铅、镉含量较高，而新生儿血中铅含量较高，镉含量较低。结论：胎盘对镉的阻隔作用强于对铅的阻隔作用。在所考察的矿化方法中，微波消解的效果最好。
Objective-To measure the concentrations of the trace elements lead and cadmium in human placenta and in maternal and neonatal (cord) blood. To assess the influence of the strongly polluted environment on the content of metals in tissues and on the permeability of placenta to cadmium and lead. Various methods of mineralisation were tested before analysis.Methods-Graphite furnace atomic absorption spectrometry was used for the determination of lead and cadmium. The samples for analysis were prepared by mineralisation under pressure in a Teflon bomb (HNO3, 110 degrees C), by wet ashing under normal pressure (HNO, + H2O, for 12 hours), and by microwave digestion in concentrated nitric acid.Results-In analysed samples the following mean concentrations of cadmium and lead were found: in venous blood Fb = 72.50 ng/ml, Cd = 4.90 ng/ml; in placenta Pb = 0.50 mu g/g, Cd = 0.11 mu g/g; in cord blood Pb = 38.31 ng/ml, Cd = 1.13 ng/ml.Conclusion-High concentrations of lead and cadmium were found in placentas and in maternal blood whereas in neonatal blood there was an increased concentration of lead and only traces of cadmium. It is concluded that the placenta is a better barrier for cadmium than for lead. Among the examined methods of mineralisation, microwave digestion was the best.