Metabonomics: a revolution in progress
Metabonomics: a revolution in progress
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发表时间：
2006-05
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通讯作者：
T. Huiru;Wang Yulan
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作者：
T. Huiru;Wang Yulan
代谢组学（Metabonomics）是定量研究完整生命系统中代谢物组成及其对内源性因素（如生理和发育）和外源性因素（如环境因素和外源性物质）变化的动态响应的科学分支。代谢组学作为一种整体研究方法，对一个完整的生物系统中与时间相关的代谢过程进行检测、量化和分类，并最终将这些过程与病理生理事件的轨迹联系起来。自1999年诞生以来，代谢组学已经在800多篇科学论文和6项专利中得到描述，其中近700篇是实验性文章。代谢组学已成为一种非常强大的分析工具，并在分子病理学和生理学、药物功效和毒性、基因修饰和功能基因组学以及环境科学等研究领域得到了成功的应用。因此，这种整体方法已成为系统生物学的重要组成部分，现在已发展成为全球系统生物学的独特组成部分。本文综述了代谢组学的基本原理和目前的一些应用，以说明代谢组学这一令人兴奋的新领域的迅速发展。
Metabonomics is the branch of science concerned with the quantitative understandings of the metabolite complement of integrated living systems and its dynamic responses to the changes of both endogenous factors (such as physiology and development) and exogenous factors (such as environmental factors and xenobiotics). As a holistic approach, metabonomics detects, quantifies and catalogues the time related metabolic processes of an integrated biological system, ultimately, relates such processes to the trajectories of the pathophysiological events. Ever since its birth in 1999, metabonomics has already been described in more than 800 scientific papers and half dozen patents, amongst which almost 700 papers were experimental articles. Now, metabonomics has been established as an extremely powerful analytical tool and hence found successful applications in many research areas including molecular pathology and physiology, drug efficacy and toxicity, gene modifications and functional genomics, and environmental sciences. This holistic approach has thus become an important part of systems biology and has now evolved to be a unique part in global systems biology. The essence of metabonomics and some of the present applications were reviewed to illustrate the rapid development of this extremely exciting new frontier.