Plasma myeloperoxidase levels in patients with chronic heart failure
Plasma myeloperoxidase levels in patients with chronic heart failure
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DOI：
10.1016/j.amjcard.2006.04.018
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发表时间：
2006-09-15
影响因子：
2.8
通讯作者：
Hazen, Stanley L.
中科院分区：
文献类型：
--
作者：
Tang, W. H. Wilson;Brennan, Marie-Luise;Hazen, Stanley L.
慢性心力衰竭（HF）患者通常观察到氧化应激增加和内皮功能障碍。髓过氧化物酶（MPO）是一种炎症标志物，与斑块易感性和心室重构异常有机制联系，但其与慢性心衰严重程度之间的关系尚未报道。测定105例正常对照（无HP和左心室功能障碍病史）和102例慢性收缩期HF（左室射血分数< 50%）患者的血浆MPO水平，并分析血浆MPO水平、血浆b型利钠肽水平和左室射血分数之间的关系。与健康对照组相比，慢性收缩期HF患者血浆MPO水平显著升高（1158 +/- 2965 pM vs 204 +/- 139 pM, p < 0.0001）。血浆MPO水平随纽约心脏协会分级的增加而增加（p < 0.0001），并与血浆b型利钠肽水平相关（Spearman’s r = 0.39, p < 0.0001）。MPO水平与HF患病率密切相关（未经校正的优势比为30.3,95%可信区间为11.1 ~ 94.5），在调整年龄和b型利钠肽后，MPO水平仍然显著（优势比为27.3,95%可信区间为3.6 ~ 371.1）。总之，在一组慢性心衰患者中，血浆MPO水平升高。与功能分级恶化有关。(c) 2006爱思唯尔公司保留所有权利。
Increased oxidative stress and endothelial dysfunction are commonly observed in patients with chronic heart failure (HF). The relation between myeloperoxidase (MPO), an inflammatory marker with mechanistic links to plaque vulnerability and abnormal ventricular remodeling, and degrees of severity in chronic HF has not been reported. Plasma MPO levels were measured in 105 normal controls (no history of HP or left ventricular dysfunction) and 102 patients with chronic systolic HF (left ventricular ejection fraction < 50%), and the relations among plasma MPO levels, plasma B-type natriuretic peptide levels, and the left ventricular ejection fraction were examined. Plasma MPO levels in patients with chronic systolic HF were significantly elevated compared with those of healthy controls (1,158 +/- 2,965 vs 204 +/- 139 pM, p < 0.0001). Plasma MPO levels increased in parallel with increasing New York Heart Association class (p < 0.0001) and were correlated with plasma B-type natriuretic peptide levels (Spearman's r = 0.39, p < 0.0001). Levels of MPO were strongly associated with the prevalence of HF (unadjusted odds ratio 30.3, 95% confidence interval 11.1 to 94.5) and remained significant when adjusted for age and B-type natriuretic peptide (odds ratio 27.3, 95% confidence interval 3.6 to 371.1). In conclusion, in a cohort of patients with chronic HF, plasma MPO levels were elevated compared with. those of normal controls and were associated with worsening functional class. (c) 2006 Elsevier Inc. All-rights reserved.