The inhibition of RNA viruses by Amaryllidaceae alkaloids: opportunities for the development of broad-spectrum anti-coronavirus drugs
The inhibition of RNA viruses by Amaryllidaceae alkaloids: opportunities for the development of broad-spectrum anti-coronavirus drugs
复制标题
石蒜科生物碱对RNA病毒的抑制：广谱抗冠状病毒药物开发的机遇
DOI：
10.1002/asia.202101215
复制
发表时间：
2022
影响因子：
4.1
通讯作者：
White Lorenzo V.
中科院分区：
文献类型：
--
作者：
Shen Tan;Banwell Martin G.;Lan Ping;White Lorenzo V.
The global COVID‐19 pandemic has claimed the lives of millions and disrupted nearly every aspect of human society. Currently, vaccines remain the only widely available medical means to address the cause of the pandemic, the SARS‐CoV‐2 virus. Unfortunately, current scientific consensus deems the emergence of vaccine‐resistant SARS‐CoV‐2 variants highly likely. In this context, the design and development of broad‐spectrum, small‐molecule based antiviral drugs has been described as a potentially effective, alternative medical strategy to address circulating and re‐emerging CoVs. Small molecules are well‐suited to target the least‐rapidly evolving structures within CoVs such as highly conserved RNA replication enzymes, and this renders them less vulnerable to evolved drug resistance. Examination of the vast literature describing the inhibition of RNA viruses byAmaryllidaceaealkaloids suggests that future, broad‐spectrum anti‐CoV drugs may be derived from this family of natural products.
