Inhibiting cell division in Escherichia coli has little if any effect on gene expression
Inhibiting cell division in Escherichia coli has little if any effect on gene expression
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DOI：
10.1128/jb.186.3.880-884.2004
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发表时间：
2004-02-01
影响因子：
3.2
通讯作者：
Weiss, DS
中科院分区：
文献类型：
--
作者：
Arends, SJR;Weiss, DS
DNA微阵列被用来比较基因表达在分裂和非分裂（丝状）培养的大肠杆菌。虽然这些培养物中的细胞在形态上有很大的不同，但它们的基因表达谱几乎相同。这些结果进一步证实了E.大肠杆菌，并且细胞周期的进展不受细胞周期不同部分期间不同基因的转录调节。
DNA microarrays were used to compare gene expression in dividing and nondividing (filamentous) cultures of Escherichia coli. Although cells from these cultures differed profoundly in morphology, their gene expression profiles were nearly identical. These results extend previous evidence that there is no division checkpoint in E. coli, and progression through the cell cycle is not regulated by the transcription of different genes during different parts of the cell cycle.